Could traditional Chinese medicine used for curing erectile dysfunction?

Chien Yu Chen, Da Tian Bau*, Ming Hsui Tsai, Yuan Man Hsu, Tin Yun Ho, Hung Jin Huang, Yea Huey Chang, Fuu Jen Tsai, Chang Hai Tsai, Calvin Yu Chian Chen

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

3 Scopus citations

Abstract

This study could show that the potent inhibitor of PDE5 from Epimedium sagittatum components. The PDE 5 inhibitors of data set from Xia's study were calculated their properties. Multiple linear regression analysis was used to build the QSAR model. Those properties were associated to drug activities by the QSAR model. This result showed high correlation (R2 = 0.848) with drug activities in this QSAR model. The weights of those properties were -5.359, 6.434, -3.959, 5.149, and 8.689. In the result of prediction, the correlation was employed to predict pIC50 of the ES series (Cialis = 7.988, ES02 = 6.31, ES03a = 9.78, ES03b = 10.03). The docking protocol was used to prove the trend of prediction. This result showed the same trend in docking scores (Cialis = 53.271, ES02 = 57.864, ES03a = 64.260, ES03b = 76.915). According to those results, ES03b was elevated to be a potent inhibitor of PDE5.

Original languageEnglish
Title of host publicationProceedings of the 2009 2nd International Conference on Biomedical Engineering and Informatics, BMEI 2009
DOIs
StatePublished - 2009
Externally publishedYes
Event2009 2nd International Conference on Biomedical Engineering and Informatics, BMEI 2009 - Tianjin, China
Duration: 17 10 200919 10 2009

Publication series

NameProceedings of the 2009 2nd International Conference on Biomedical Engineering and Informatics, BMEI 2009

Conference

Conference2009 2nd International Conference on Biomedical Engineering and Informatics, BMEI 2009
Country/TerritoryChina
CityTianjin
Period17/10/0919/10/09

Keywords

  • Docking
  • Epimedium sagittatum
  • Erectile dysfunction
  • Phosphodiesterase5

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