CPP antagonizes hypoxia-induced changes in dopamine metabolism in the striatum of newborn rat

Meng Fai Kuo; Ruey Meei Wu; Huei Shyong Wang; Swei Ming Lin

doi:10.1016/S0168-0102(99)00084-X

CPP antagonizes hypoxia-induced changes in dopamine metabolism in the striatum of newborn rat

Meng Fai Kuo, Ruey Meei Wu, Huei Shyong Wang, Swei Ming Lin

Research output: Contribution to journal › Journal Article › peer-review

3 Scopus citations

Abstract

Treatment with 3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP), a potent and competitive N-methyl-D-aspartate antagonist, is able to reduce the hypoxia-induced increase in striatal dopamine level by 26% even after the hypoxic insult has occurred. The hypoxia-induced decrease of the striatal 3,4-dihydroxyphenylacetic acid level can also be reversed by CPP. This study demonstrates that CPP can antagonize the hypoxia-induced changes in the dopamine metabolism in the striatum of the newborn rat. Copyright (C) 1999 Elsevier Science Ireland Ltd.

Original language	English
Pages (from-to)	347-350
Number of pages	4
Journal	Neuroscience Research
Volume	35
Issue number	4
DOIs	https://doi.org/10.1016/S0168-0102(99)00084-X
State	Published - 30 12 1999
Externally published	Yes

Keywords

CPP
Dopamine
Hypoxia
NMDA receptor antagonist
Newborn rats
Striatum

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10.1016/S0168-0102(99)00084-X

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title = "CPP antagonizes hypoxia-induced changes in dopamine metabolism in the striatum of newborn rat",

abstract = "Treatment with 3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP), a potent and competitive N-methyl-D-aspartate antagonist, is able to reduce the hypoxia-induced increase in striatal dopamine level by 26% even after the hypoxic insult has occurred. The hypoxia-induced decrease of the striatal 3,4-dihydroxyphenylacetic acid level can also be reversed by CPP. This study demonstrates that CPP can antagonize the hypoxia-induced changes in the dopamine metabolism in the striatum of the newborn rat. Copyright (C) 1999 Elsevier Science Ireland Ltd.",

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T1 - CPP antagonizes hypoxia-induced changes in dopamine metabolism in the striatum of newborn rat

AU - Kuo, Meng Fai

AU - Wu, Ruey Meei

AU - Wang, Huei Shyong

AU - Lin, Swei Ming

PY - 1999/12/30

Y1 - 1999/12/30

N2 - Treatment with 3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP), a potent and competitive N-methyl-D-aspartate antagonist, is able to reduce the hypoxia-induced increase in striatal dopamine level by 26% even after the hypoxic insult has occurred. The hypoxia-induced decrease of the striatal 3,4-dihydroxyphenylacetic acid level can also be reversed by CPP. This study demonstrates that CPP can antagonize the hypoxia-induced changes in the dopamine metabolism in the striatum of the newborn rat. Copyright (C) 1999 Elsevier Science Ireland Ltd.

AB - Treatment with 3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP), a potent and competitive N-methyl-D-aspartate antagonist, is able to reduce the hypoxia-induced increase in striatal dopamine level by 26% even after the hypoxic insult has occurred. The hypoxia-induced decrease of the striatal 3,4-dihydroxyphenylacetic acid level can also be reversed by CPP. This study demonstrates that CPP can antagonize the hypoxia-induced changes in the dopamine metabolism in the striatum of the newborn rat. Copyright (C) 1999 Elsevier Science Ireland Ltd.

KW - CPP

KW - Dopamine

KW - Hypoxia

KW - NMDA receptor antagonist

KW - Newborn rats

KW - Striatum

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AN - SCOPUS:0032742367

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SP - 347

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ER -

CPP antagonizes hypoxia-induced changes in dopamine metabolism in the striatum of newborn rat

Abstract

Keywords

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