CPP antagonizes hypoxia-induced changes in dopamine metabolism in the striatum of newborn rat

Meng Fai Kuo; Ruey Meei Wu; Huei Shyong Wang; Swei Ming Lin

doi:10.1016/S0168-0102(99)00084-X

CPP antagonizes hypoxia-induced changes in dopamine metabolism in the striatum of newborn rat

Meng Fai Kuo
, Ruey Meei Wu
, Huei Shyong Wang
, Swei Ming Lin

Research output: Contribution to journal › Journal Article › peer-review

3 Scopus citations

Abstract

Treatment with 3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP), a potent and competitive N-methyl-D-aspartate antagonist, is able to reduce the hypoxia-induced increase in striatal dopamine level by 26% even after the hypoxic insult has occurred. The hypoxia-induced decrease of the striatal 3,4-dihydroxyphenylacetic acid level can also be reversed by CPP. This study demonstrates that CPP can antagonize the hypoxia-induced changes in the dopamine metabolism in the striatum of the newborn rat. Copyright (C) 1999 Elsevier Science Ireland Ltd.

Original language	English
Pages (from-to)	347-350
Number of pages	4
Journal	Neuroscience Research
Volume	35
Issue number	4
DOIs	https://doi.org/10.1016/S0168-0102(99)00084-X
State	Published - 30 12 1999
Externally published	Yes

Keywords

CPP
Dopamine
Hypoxia
NMDA receptor antagonist
Newborn rats
Striatum

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10.1016/S0168-0102(99)00084-X

Cite this

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title = "CPP antagonizes hypoxia-induced changes in dopamine metabolism in the striatum of newborn rat",

abstract = "Treatment with 3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP), a potent and competitive N-methyl-D-aspartate antagonist, is able to reduce the hypoxia-induced increase in striatal dopamine level by 26\% even after the hypoxic insult has occurred. The hypoxia-induced decrease of the striatal 3,4-dihydroxyphenylacetic acid level can also be reversed by CPP. This study demonstrates that CPP can antagonize the hypoxia-induced changes in the dopamine metabolism in the striatum of the newborn rat. Copyright (C) 1999 Elsevier Science Ireland Ltd.",

keywords = "CPP, Dopamine, Hypoxia, NMDA receptor antagonist, Newborn rats, Striatum",

author = "Kuo, \{Meng Fai\} and Wu, \{Ruey Meei\} and Wang, \{Huei Shyong\} and Lin, \{Swei Ming\}",

year = "1999",

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doi = "10.1016/S0168-0102(99)00084-X",

language = "英语",

volume = "35",

pages = "347--350",

journal = "Neuroscience Research",

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T1 - CPP antagonizes hypoxia-induced changes in dopamine metabolism in the striatum of newborn rat

AU - Kuo, Meng Fai

AU - Wu, Ruey Meei

AU - Wang, Huei Shyong

AU - Lin, Swei Ming

PY - 1999/12/30

Y1 - 1999/12/30

N2 - Treatment with 3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP), a potent and competitive N-methyl-D-aspartate antagonist, is able to reduce the hypoxia-induced increase in striatal dopamine level by 26% even after the hypoxic insult has occurred. The hypoxia-induced decrease of the striatal 3,4-dihydroxyphenylacetic acid level can also be reversed by CPP. This study demonstrates that CPP can antagonize the hypoxia-induced changes in the dopamine metabolism in the striatum of the newborn rat. Copyright (C) 1999 Elsevier Science Ireland Ltd.

AB - Treatment with 3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP), a potent and competitive N-methyl-D-aspartate antagonist, is able to reduce the hypoxia-induced increase in striatal dopamine level by 26% even after the hypoxic insult has occurred. The hypoxia-induced decrease of the striatal 3,4-dihydroxyphenylacetic acid level can also be reversed by CPP. This study demonstrates that CPP can antagonize the hypoxia-induced changes in the dopamine metabolism in the striatum of the newborn rat. Copyright (C) 1999 Elsevier Science Ireland Ltd.

KW - CPP

KW - Dopamine

KW - Hypoxia

KW - NMDA receptor antagonist

KW - Newborn rats

KW - Striatum

UR - https://www.scopus.com/pages/publications/0032742367

U2 - 10.1016/S0168-0102(99)00084-X

DO - 10.1016/S0168-0102(99)00084-X

M3 - 文章

C2 - 10617326

AN - SCOPUS:0032742367

SN - 0168-0102

VL - 35

SP - 347

EP - 350

JO - Neuroscience Research

JF - Neuroscience Research

IS - 4

ER -

CPP antagonizes hypoxia-induced changes in dopamine metabolism in the striatum of newborn rat

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Keywords

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