Curcuphenol derivatives from the gorgonian Echinomuricea sp.

Hsu Ming Chung; Tsong Long Hwang; Wei Hsien Wang; Lee Shing Fang; Ping Jyun Sung

doi:10.3987/COM-09-11771

Curcuphenol derivatives from the gorgonian Echinomuricea sp.

Hsu Ming Chung^*, Tsong Long Hwang, Wei Hsien Wang, Lee Shing Fang, Ping Jyun Sung

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

10 Scopus citations

Abstract

Two sesquiterpenoid phenols, including a new natural product 1 [(7S, 10R)-(+)-10,11-epoxycurcuphenol] and a known metabolite, (+)-curcuphenol (2), were isolated from a gorgonian coral identified as Echinomuricea sp. The structures of 1 and 2 were elucidated by interpretations of spectral data and by comparison of the related physical and spectral data with those of related metabolites. Compound 2 was found to show significant inhibitory effects on elastase release by human neutrophils.

Original language	English
Pages (from-to)	2595-2600
Number of pages	6
Journal	Heterocycles
Volume	78
Issue number	10
DOIs	https://doi.org/10.3987/COM-09-11771
State	Published - 01 10 2009

Keywords

Curcuphenol
Echinomuricea
Elastase
Gorgonian
Superoxide Anion

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title = "Curcuphenol derivatives from the gorgonian Echinomuricea sp.",

abstract = "Two sesquiterpenoid phenols, including a new natural product 1 [(7S, 10R)-(+)-10,11-epoxycurcuphenol] and a known metabolite, (+)-curcuphenol (2), were isolated from a gorgonian coral identified as Echinomuricea sp. The structures of 1 and 2 were elucidated by interpretations of spectral data and by comparison of the related physical and spectral data with those of related metabolites. Compound 2 was found to show significant inhibitory effects on elastase release by human neutrophils.",

keywords = "Curcuphenol, Echinomuricea, Elastase, Gorgonian, Superoxide Anion",

author = "Chung, {Hsu Ming} and Hwang, {Tsong Long} and Wang, {Wei Hsien} and Fang, {Lee Shing} and Sung, {Ping Jyun}",

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AU - Chung, Hsu Ming

AU - Hwang, Tsong Long

AU - Wang, Wei Hsien

AU - Fang, Lee Shing

AU - Sung, Ping Jyun

PY - 2009/10/1

Y1 - 2009/10/1

N2 - Two sesquiterpenoid phenols, including a new natural product 1 [(7S, 10R)-(+)-10,11-epoxycurcuphenol] and a known metabolite, (+)-curcuphenol (2), were isolated from a gorgonian coral identified as Echinomuricea sp. The structures of 1 and 2 were elucidated by interpretations of spectral data and by comparison of the related physical and spectral data with those of related metabolites. Compound 2 was found to show significant inhibitory effects on elastase release by human neutrophils.

AB - Two sesquiterpenoid phenols, including a new natural product 1 [(7S, 10R)-(+)-10,11-epoxycurcuphenol] and a known metabolite, (+)-curcuphenol (2), were isolated from a gorgonian coral identified as Echinomuricea sp. The structures of 1 and 2 were elucidated by interpretations of spectral data and by comparison of the related physical and spectral data with those of related metabolites. Compound 2 was found to show significant inhibitory effects on elastase release by human neutrophils.

KW - Curcuphenol

KW - Echinomuricea

KW - Elastase

KW - Gorgonian

KW - Superoxide Anion

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M3 - 文章

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VL - 78

SP - 2595

EP - 2600

JO - Heterocycles

JF - Heterocycles

IS - 10

ER -

Curcuphenol derivatives from the gorgonian Echinomuricea sp.

Abstract

Keywords

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