Current Advances in Cellular Approaches for Pathophysiology and Treatment of Polycystic Ovary Syndrome

Yi Ru Tsai, Yen Nung Liao, Hong Yo Kang*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Polycystic ovary syndrome (PCOS) is a prevalent gynecological and endocrine disorder that results in irregular menstruation, incomplete follicular development, disrupted ovulation, and reduced fertility rates among affected women of reproductive age. While these symptoms can be managed through appropriate medication and lifestyle interventions, both etiology and treatment options remain limited. Here we provide a comprehensive overview of the latest advancements in cellular approaches utilized for investigating the pathophysiology of PCOS through in vitro cell models, to avoid the confounding systemic effects such as in vitro fertilization (IVF) therapy. The primary objective is to enhance the understanding of abnormalities in PCOS-associated folliculogenesis, particularly focusing on the aberrant roles of granulosa cells and other relevant cell types. Furthermore, this article encompasses analyses of the mechanisms and signaling pathways, microRNA expression and target genes altered in PCOS, and explores the pharmacological approaches considered as potential treatments. By summarizing the aforementioned key findings, this article not only allows us to appreciate the value of using in vitro cell models, but also provides guidance for selecting suitable research models to facilitate the identification of potential treatments and understand the pathophysiology of PCOS at the cellular level.

Original languageEnglish
Article number2189
JournalCells
Volume12
Issue number17
DOIs
StatePublished - 09 2023

Bibliographical note

Publisher Copyright:
© 2023 by the authors.

Keywords

  • androgen receptor
  • folliculogenesis
  • granulosa cells
  • hyperandrogenism
  • polycystic ovary syndrome

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