Current concepts of the structure and nature of mammalian salivary mucous glycoproteins

Anthony Herp; Albert M. Wu; John Moschera

doi:10.1007/BF00226677

Current concepts of the structure and nature of mammalian salivary mucous glycoproteins

Anthony Herp^*, Albert M. Wu, John Moschera

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

98 Scopus citations

Abstract

The visco-elastic properties of salivary secretions are due to high molecular-weight glyco-proteins, known as mucins. Mucins are composed of numerous oligosaccharide side-chains O-glycosidically linked through 2-acetamido-2deoxy-α-d-galactose to the hydroxyl groups of seryl and threonyl residues of the protein core; on the average, every fourth amino acid residue is involved in such a bond. This work conveys their isolation and purification, compiles the compositional analysis of several mammalian submaxillary and sublingual mucins; defines the conditions of the alkaline β-elimination reaction, its mechanism and importance in structural studies of glycoproteins, and briefly discusses the influence of stimuli on mucous secretions, as well as biosynthesis, structural diversity, and physiological role of salivary mucous glycoproteins.

Original language	English
Pages (from-to)	27-44
Number of pages	18
Journal	Molecular and Cellular Biochemistry
Volume	23
Issue number	1
DOIs	https://doi.org/10.1007/BF00226677
State	Published - 01 1979
Externally published	Yes

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AB - The visco-elastic properties of salivary secretions are due to high molecular-weight glyco-proteins, known as mucins. Mucins are composed of numerous oligosaccharide side-chains O-glycosidically linked through 2-acetamido-2deoxy-α-d-galactose to the hydroxyl groups of seryl and threonyl residues of the protein core; on the average, every fourth amino acid residue is involved in such a bond. This work conveys their isolation and purification, compiles the compositional analysis of several mammalian submaxillary and sublingual mucins; defines the conditions of the alkaline β-elimination reaction, its mechanism and importance in structural studies of glycoproteins, and briefly discusses the influence of stimuli on mucous secretions, as well as biosynthesis, structural diversity, and physiological role of salivary mucous glycoproteins.

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Current concepts of the structure and nature of mammalian salivary mucous glycoproteins

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