Current trends of microfluidic single-cell technologies

Pallavi Shinde; Loganathan Mohan; Amogh Kumar; Koyel Dey; Anjali Maddi; Alexander N. Patananan; Fan Gang Tseng; Hwan You Chang; Moeto Nagai; Tuhin Subhra Santra

doi:10.3390/ijms19103143

Current trends of microfluidic single-cell technologies

Pallavi Shinde, Loganathan Mohan, Amogh Kumar, Koyel Dey, Anjali Maddi, Alexander N. Patananan, Fan Gang Tseng, Hwan You Chang, Moeto Nagai, Tuhin Subhra Santra^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

63 Scopus citations

Abstract

The investigation of human disease mechanisms is difficult due to the heterogeneity in gene expression and the physiological state of cells in a given population. In comparison to bulk cell measurements, single-cell measurement technologies can provide a better understanding of the interactions among molecules, organelles, cells, and the microenvironment, which can aid in the development of therapeutics and diagnostic tools. In recent years, single-cell technologies have become increasingly robust and accessible, although limitations exist. In this review, we describe the recent advances in single-cell technologies and their applications in single-cell manipulation, diagnosis, and therapeutics development.

Original language	English
Article number	3143
Journal	International Journal of Molecular Sciences
Volume	19
Issue number	10
DOIs	https://doi.org/10.3390/ijms19103143
State	Published - 12 10 2018
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2018 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

Diagnosis
Drug delivery
Lab-on-a-chip
Manipulation
Microfluidics bio-MEMS
Single-cell
Therapeutics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/ijms19103143

Cite this

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abstract = "The investigation of human disease mechanisms is difficult due to the heterogeneity in gene expression and the physiological state of cells in a given population. In comparison to bulk cell measurements, single-cell measurement technologies can provide a better understanding of the interactions among molecules, organelles, cells, and the microenvironment, which can aid in the development of therapeutics and diagnostic tools. In recent years, single-cell technologies have become increasingly robust and accessible, although limitations exist. In this review, we describe the recent advances in single-cell technologies and their applications in single-cell manipulation, diagnosis, and therapeutics development.",

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AU - Shinde, Pallavi

AU - Mohan, Loganathan

AU - Kumar, Amogh

AU - Dey, Koyel

AU - Maddi, Anjali

AU - Patananan, Alexander N.

AU - Tseng, Fan Gang

AU - Chang, Hwan You

AU - Nagai, Moeto

AU - Santra, Tuhin Subhra

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N2 - The investigation of human disease mechanisms is difficult due to the heterogeneity in gene expression and the physiological state of cells in a given population. In comparison to bulk cell measurements, single-cell measurement technologies can provide a better understanding of the interactions among molecules, organelles, cells, and the microenvironment, which can aid in the development of therapeutics and diagnostic tools. In recent years, single-cell technologies have become increasingly robust and accessible, although limitations exist. In this review, we describe the recent advances in single-cell technologies and their applications in single-cell manipulation, diagnosis, and therapeutics development.

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KW - Drug delivery

KW - Lab-on-a-chip

KW - Manipulation

KW - Microfluidics bio-MEMS

KW - Single-cell

KW - Therapeutics

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M3 - 文献综述

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Current trends of microfluidic single-cell technologies

Abstract

Bibliographical note

Keywords

UN SDGs

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