Cutaneous intravascular NK-cell lymphoma: Report of a rare variant associated with Epstein-Barr virus

Tseng Tong Kuo*, Ming Jing Chen, Ming Chung Kuo

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

47 Scopus citations

Abstract

Intravascular lymphoma (IVL) is a rare variant of non-Hodgkin lymphoma with a predilection for skin and brain. Except a few cases of T-cell lineage, most of the reported cases were large B-cell lymphomas. We encountered a case of cutaneous IVL in a 71-year-old woman presenting with multiple erythematous patches and nodules on her trunk and extremities. The intravascular large cells showed an immunophenotype of CD3ε+, CD5-, CD20 -, CD30-, CD56+, and TIA-1+. The lymphoma cells were also positive for Epstein-Barr virus by Epstein-Barr virus-encoded RNA in situ hybridization test and the T-cell receptor gene was germline. This IVL differs from nasal type NK/T-cell lymphoma only by its intravascular nature. Only 3 cases of intravascular NK-cell lymphoma have been reported before. Because this variant is extremely rare, our case is documented and compared with the 3 previously reported cases.

Original languageEnglish
Pages (from-to)1197-1201
Number of pages5
JournalAmerican Journal of Surgical Pathology
Volume30
Issue number9
DOIs
StatePublished - 09 2006

Keywords

  • Epstein-Barr virus
  • Intravascular lymphoma
  • NK-cell lymphoma

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