Cyclopeptides with anti-inflammatory activity from seeds of Annona montana

Pei Hsuan Chuang; Pei Wen Hsieh; Yu Liang Yang; Kuo Feng Hua; Fang Rong Chang; Jentaie Shiea; Shih Hsiung Wu; Yang Chang Wu

doi:10.1021/np8001282

Cyclopeptides with anti-inflammatory activity from seeds of Annona montana

Pei Hsuan Chuang, Pei Wen Hsieh, Yu Liang Yang, Kuo Feng Hua, Fang Rong Chang, Jentaie Shiea, Shih Hsiung Wu, Yang Chang Wu^*

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

51 Scopus citations

Abstract

Four new cyclopeptides, cyclomontanins A-D (1-4), annomuricatin C (5), and (+)-corytuberine were isolated from a methanol extract of Annona montana seeds. Their structures were elucidated by 2D NMR analysis, ESIMS/MS fragment evidence, and chemical means. The structure of 1 was confirmed by synthesis. Compounds 1, 3, and 4 exhibited anti-inflammatory activity in vitro using the J774.1 macrophage model.

Original language	English
Pages (from-to)	1365-1370
Number of pages	6
Journal	Journal of Natural Products
Volume	71
Issue number	8
DOIs	https://doi.org/10.1021/np8001282
State	Published - 08 2008

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title = "Cyclopeptides with anti-inflammatory activity from seeds of Annona montana",

abstract = "Four new cyclopeptides, cyclomontanins A-D (1-4), annomuricatin C (5), and (+)-corytuberine were isolated from a methanol extract of Annona montana seeds. Their structures were elucidated by 2D NMR analysis, ESIMS/MS fragment evidence, and chemical means. The structure of 1 was confirmed by synthesis. Compounds 1, 3, and 4 exhibited anti-inflammatory activity in vitro using the J774.1 macrophage model.",

author = "Chuang, {Pei Hsuan} and Hsieh, {Pei Wen} and Yang, {Yu Liang} and Hua, {Kuo Feng} and Chang, {Fang Rong} and Jentaie Shiea and Wu, {Shih Hsiung} and Wu, {Yang Chang}",

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doi = "10.1021/np8001282",

language = "英语",

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AU - Chuang, Pei Hsuan

AU - Hsieh, Pei Wen

AU - Yang, Yu Liang

AU - Hua, Kuo Feng

AU - Chang, Fang Rong

AU - Shiea, Jentaie

AU - Wu, Shih Hsiung

AU - Wu, Yang Chang

PY - 2008/8

Y1 - 2008/8

N2 - Four new cyclopeptides, cyclomontanins A-D (1-4), annomuricatin C (5), and (+)-corytuberine were isolated from a methanol extract of Annona montana seeds. Their structures were elucidated by 2D NMR analysis, ESIMS/MS fragment evidence, and chemical means. The structure of 1 was confirmed by synthesis. Compounds 1, 3, and 4 exhibited anti-inflammatory activity in vitro using the J774.1 macrophage model.

AB - Four new cyclopeptides, cyclomontanins A-D (1-4), annomuricatin C (5), and (+)-corytuberine were isolated from a methanol extract of Annona montana seeds. Their structures were elucidated by 2D NMR analysis, ESIMS/MS fragment evidence, and chemical means. The structure of 1 was confirmed by synthesis. Compounds 1, 3, and 4 exhibited anti-inflammatory activity in vitro using the J774.1 macrophage model.

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U2 - 10.1021/np8001282

DO - 10.1021/np8001282

M3 - 文章

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AN - SCOPUS:51849113677

SN - 0163-3864

VL - 71

SP - 1365

EP - 1370

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 8

ER -

Cyclopeptides with anti-inflammatory activity from seeds of Annona montana

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