Cyclosporine Anionic and Cationic Ophthalmic Emulsions in Dry Eye Disease: A Literature Review

Louis Tong*, Chi Chin Sun, Kyung Chul Yoon, Ruben Lim Bon Siong, Vilavun Puangsricharern, Christophe Baudouin

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Purpose: There are no clinical studies directly comparing anionic and cationic emulsions of cyclosporine for the treatment of dry eye disease (DED). We therefore conducted a literature review to evaluate the efficacy and safety of these different formulations. Methods: A literature search was performed in Embase and Medline from January 1999 to May 2019 to identify publications that evaluated clinical outcomes with either cyclosporine anionic or cationic emulsion in patients with moderate-to-severe or severe DED. Results: Thirteen publications met criteria. In patients with moderate-to-severe disease, evidence demonstrated improvement in the signs of DED with both formulations. However, improvement in symptoms was not consistently demonstrated. Studies specifically in severe DED were only identified with the cationic emulsion and showed improvement in the objective signs of DED. There were no obvious differences in tolerability between products. Conclusions: Both formulations are effective for the treatment of moderate-to-severe DED and are well tolerated.

Original languageEnglish
Pages (from-to)1606-1615
Number of pages10
JournalOcular Immunology and Inflammation
Volume29
Issue number7-8
DOIs
StatePublished - 2021

Bibliographical note

Publisher Copyright:
© 2020 Taylor & Francis Group, LLC.

Keywords

  • Cyclosporine
  • anionic
  • cationic
  • dry eye disease
  • formulation

Fingerprint

Dive into the research topics of 'Cyclosporine Anionic and Cationic Ophthalmic Emulsions in Dry Eye Disease: A Literature Review'. Together they form a unique fingerprint.

Cite this