Cyclosporine enhances vasorelaxation in coronary but not pulmonary artery after 16-hour preservation with UW solution

Y. Chu; Y. C. Wu; Y. C. Chou; H. P. Liu; J. J. Chu; P. J. Lin

doi:10.1016/j.transproceed.2003.10.071

Cyclosporine enhances vasorelaxation in coronary but not pulmonary artery after 16-hour preservation with UW solution

Y. Chu, Y. C. Wu, Y. C. Chou, H. P. Liu, J. J. Chu, P. J. Lin^*

^*Corresponding author for this work

Chang Gung Memorial Hospital

Research output: Contribution to journal › Journal Article › peer-review

2 Scopus citations

Abstract

Cyclosporine (CsA), a calcineurin inhibitor, has been associated with endothelial dysfunction in transplant patients. Human and in vitro studies suggest that CsA produces endothelial dysfunction by impairing vascular endothelium-dependent relaxation. However, little is know about the CsA effects to modulate the vasorelaxation after prolonged graft preservation. In this study using a protocol designed to eliminate the influences of infusion pressure and shear stress, we evaluated the effect of CsA on vasorelaxation of coronary and pulmonary arteries after 16-hour University of Wisconsin (UW) solution preservation.

Original language	English
Pages (from-to)	3139-3141
Number of pages	3
Journal	Transplantation Proceedings
Volume	35
Issue number	8
DOIs	https://doi.org/10.1016/j.transproceed.2003.10.071
State	Published - 12 2003
Externally published	Yes

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10.1016/j.transproceed.2003.10.071

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title = "Cyclosporine enhances vasorelaxation in coronary but not pulmonary artery after 16-hour preservation with UW solution",

abstract = "Cyclosporine (CsA), a calcineurin inhibitor, has been associated with endothelial dysfunction in transplant patients. Human and in vitro studies suggest that CsA produces endothelial dysfunction by impairing vascular endothelium-dependent relaxation. However, little is know about the CsA effects to modulate the vasorelaxation after prolonged graft preservation. In this study using a protocol designed to eliminate the influences of infusion pressure and shear stress, we evaluated the effect of CsA on vasorelaxation of coronary and pulmonary arteries after 16-hour University of Wisconsin (UW) solution preservation.",

author = "Y. Chu and Wu, {Y. C.} and Chou, {Y. C.} and Liu, {H. P.} and Chu, {J. J.} and Lin, {P. J.}",

year = "2003",

month = dec,

doi = "10.1016/j.transproceed.2003.10.071",

language = "英语",

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pages = "3139--3141",

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T1 - Cyclosporine enhances vasorelaxation in coronary but not pulmonary artery after 16-hour preservation with UW solution

AU - Chu, Y.

AU - Wu, Y. C.

AU - Chou, Y. C.

AU - Liu, H. P.

AU - Chu, J. J.

AU - Lin, P. J.

PY - 2003/12

Y1 - 2003/12

N2 - Cyclosporine (CsA), a calcineurin inhibitor, has been associated with endothelial dysfunction in transplant patients. Human and in vitro studies suggest that CsA produces endothelial dysfunction by impairing vascular endothelium-dependent relaxation. However, little is know about the CsA effects to modulate the vasorelaxation after prolonged graft preservation. In this study using a protocol designed to eliminate the influences of infusion pressure and shear stress, we evaluated the effect of CsA on vasorelaxation of coronary and pulmonary arteries after 16-hour University of Wisconsin (UW) solution preservation.

AB - Cyclosporine (CsA), a calcineurin inhibitor, has been associated with endothelial dysfunction in transplant patients. Human and in vitro studies suggest that CsA produces endothelial dysfunction by impairing vascular endothelium-dependent relaxation. However, little is know about the CsA effects to modulate the vasorelaxation after prolonged graft preservation. In this study using a protocol designed to eliminate the influences of infusion pressure and shear stress, we evaluated the effect of CsA on vasorelaxation of coronary and pulmonary arteries after 16-hour University of Wisconsin (UW) solution preservation.

UR - http://www.scopus.com/inward/record.url?scp=0347761547&partnerID=8YFLogxK

U2 - 10.1016/j.transproceed.2003.10.071

DO - 10.1016/j.transproceed.2003.10.071

M3 - 文章

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AN - SCOPUS:0347761547

SN - 0041-1345

VL - 35

SP - 3139

EP - 3141

JO - Transplantation Proceedings

JF - Transplantation Proceedings

IS - 8

ER -

Cyclosporine enhances vasorelaxation in coronary but not pulmonary artery after 16-hour preservation with UW solution

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