Cytotoxic ent-abietane diterpenes from Gelonium aequoreum

Chia Lin Lee; Fang Rong Chang; Pei Wen Hsieh; Michael Y. Chiang; Chin Chung Wu; Zih You Huang; Yu Hsuan Lan; Mei Chen; Kuo Hsiung Lee; Hsin Fu Yen; Wen Chun Hung; Yang Chang Wu

doi:10.1016/j.phytochem.2007.07.005

Cytotoxic ent-abietane diterpenes from Gelonium aequoreum

Chia Lin Lee, Fang Rong Chang, Pei Wen Hsieh, Michael Y. Chiang, Chin Chung Wu, Zih You Huang, Yu Hsuan Lan, Mei Chen, Kuo Hsiung Lee, Hsin Fu Yen, Wen Chun Hung, Yang Chang Wu^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

28 Scopus citations

Abstract

Seventeen ent-abietane diterpenes, including gelomulides K-X (1-14), and three known compounds, were isolated from a dichloromethane-soluble extract of Gelonium aequoreum through bioassay-guided fractionation. Their structures were identified by spectroscopic methods, and stereochemistry was confirmed by X-ray crystallographic analysis, CD spectral data, and Mosher's method. The isolates were evaluated for in vitro cytotoxic activity, and compounds 1 and 3 showed moderate cytotoxicity against lung (A549), breast (MDA-MB-231 and MCF7), and liver (HepG2) cancer cell lines.

Original language	English
Pages (from-to)	276-287
Number of pages	12
Journal	Phytochemistry
Volume	69
Issue number	1
DOIs	https://doi.org/10.1016/j.phytochem.2007.07.005
State	Published - 01 2008
Externally published	Yes

Keywords

Cytotoxicity
Euphorbiaceae
Gelomulides K-X
Gelonium aequoreum
ent-Abietane diterpenes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.phytochem.2007.07.005

Cite this

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title = "Cytotoxic ent-abietane diterpenes from Gelonium aequoreum",

abstract = "Seventeen ent-abietane diterpenes, including gelomulides K-X (1-14), and three known compounds, were isolated from a dichloromethane-soluble extract of Gelonium aequoreum through bioassay-guided fractionation. Their structures were identified by spectroscopic methods, and stereochemistry was confirmed by X-ray crystallographic analysis, CD spectral data, and Mosher's method. The isolates were evaluated for in vitro cytotoxic activity, and compounds 1 and 3 showed moderate cytotoxicity against lung (A549), breast (MDA-MB-231 and MCF7), and liver (HepG2) cancer cell lines.",

keywords = "Cytotoxicity, Euphorbiaceae, Gelomulides K-X, Gelonium aequoreum, ent-Abietane diterpenes",

author = "Lee, \{Chia Lin\} and Chang, \{Fang Rong\} and Hsieh, \{Pei Wen\} and Chiang, \{Michael Y.\} and Wu, \{Chin Chung\} and Huang, \{Zih You\} and Lan, \{Yu Hsuan\} and Mei Chen and Lee, \{Kuo Hsiung\} and Yen, \{Hsin Fu\} and Hung, \{Wen Chun\} and Wu, \{Yang Chang\}",

year = "2008",

month = jan,

doi = "10.1016/j.phytochem.2007.07.005",

language = "英语",

volume = "69",

pages = "276--287",

journal = "Phytochemistry",

issn = "0031-9422",

publisher = "Elsevier Ltd",

number = "1",

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TY - JOUR

T1 - Cytotoxic ent-abietane diterpenes from Gelonium aequoreum

AU - Lee, Chia Lin

AU - Chang, Fang Rong

AU - Hsieh, Pei Wen

AU - Chiang, Michael Y.

AU - Wu, Chin Chung

AU - Huang, Zih You

AU - Lan, Yu Hsuan

AU - Chen, Mei

AU - Lee, Kuo Hsiung

AU - Yen, Hsin Fu

AU - Hung, Wen Chun

AU - Wu, Yang Chang

PY - 2008/1

Y1 - 2008/1

N2 - Seventeen ent-abietane diterpenes, including gelomulides K-X (1-14), and three known compounds, were isolated from a dichloromethane-soluble extract of Gelonium aequoreum through bioassay-guided fractionation. Their structures were identified by spectroscopic methods, and stereochemistry was confirmed by X-ray crystallographic analysis, CD spectral data, and Mosher's method. The isolates were evaluated for in vitro cytotoxic activity, and compounds 1 and 3 showed moderate cytotoxicity against lung (A549), breast (MDA-MB-231 and MCF7), and liver (HepG2) cancer cell lines.

AB - Seventeen ent-abietane diterpenes, including gelomulides K-X (1-14), and three known compounds, were isolated from a dichloromethane-soluble extract of Gelonium aequoreum through bioassay-guided fractionation. Their structures were identified by spectroscopic methods, and stereochemistry was confirmed by X-ray crystallographic analysis, CD spectral data, and Mosher's method. The isolates were evaluated for in vitro cytotoxic activity, and compounds 1 and 3 showed moderate cytotoxicity against lung (A549), breast (MDA-MB-231 and MCF7), and liver (HepG2) cancer cell lines.

KW - Cytotoxicity

KW - Euphorbiaceae

KW - Gelomulides K-X

KW - Gelonium aequoreum

KW - ent-Abietane diterpenes

UR - http://www.scopus.com/inward/record.url?scp=37149040418&partnerID=8YFLogxK

U2 - 10.1016/j.phytochem.2007.07.005

DO - 10.1016/j.phytochem.2007.07.005

M3 - 文章

C2 - 17714747

AN - SCOPUS:37149040418

SN - 0031-9422

VL - 69

SP - 276

EP - 287

JO - Phytochemistry

JF - Phytochemistry

IS - 1

ER -

Cytotoxic ent-abietane diterpenes from Gelonium aequoreum

Abstract

Keywords

UN SDGs

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