Cytotoxic ent-abietane diterpenes from Gelonium aequoreum

Chia Lin Lee, Fang Rong Chang, Pei Wen Hsieh, Michael Y. Chiang, Chin Chung Wu, Zih You Huang, Yu Hsuan Lan, Mei Chen, Kuo Hsiung Lee, Hsin Fu Yen, Wen Chun Hung, Yang Chang Wu*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

28 Scopus citations

Abstract

Seventeen ent-abietane diterpenes, including gelomulides K-X (1-14), and three known compounds, were isolated from a dichloromethane-soluble extract of Gelonium aequoreum through bioassay-guided fractionation. Their structures were identified by spectroscopic methods, and stereochemistry was confirmed by X-ray crystallographic analysis, CD spectral data, and Mosher's method. The isolates were evaluated for in vitro cytotoxic activity, and compounds 1 and 3 showed moderate cytotoxicity against lung (A549), breast (MDA-MB-231 and MCF7), and liver (HepG2) cancer cell lines.

Original languageEnglish
Pages (from-to)276-287
Number of pages12
JournalPhytochemistry
Volume69
Issue number1
DOIs
StatePublished - 01 2008
Externally publishedYes

Keywords

  • Cytotoxicity
  • Euphorbiaceae
  • Gelomulides K-X
  • Gelonium aequoreum
  • ent-Abietane diterpenes

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