Cytotoxic ent-abietane diterpenes from Gelonium aequoreum

Chia Lin Lee; Fang Rong Chang; Pei Wen Hsieh; Michael Y. Chiang; Chin Chung Wu; Zih You Huang; Yu Hsuan Lan; Mei Chen; Kuo Hsiung Lee; Hsin Fu Yen; Wen Chun Hung; Yang Chang Wu

doi:10.1016/j.phytochem.2007.07.005

Cytotoxic ent-abietane diterpenes from Gelonium aequoreum

Chia Lin Lee
, Fang Rong Chang
, Pei Wen Hsieh
, Michael Y. Chiang
, Chin Chung Wu
, Zih You Huang
, Yu Hsuan Lan
, Mei Chen
, Kuo Hsiung Lee
, Hsin Fu Yen
, Wen Chun Hung
, Yang Chang Wu^*

^*Corresponding author for this work

Kaohsiung Medical University
National Sun Yat-sen University
University of North Carolina at Chapel Hill
National Museum of Natural Science, Taiwan

Research output: Contribution to journal › Journal Article › peer-review

29 Scopus citations

Abstract

Seventeen ent-abietane diterpenes, including gelomulides K-X (1-14), and three known compounds, were isolated from a dichloromethane-soluble extract of Gelonium aequoreum through bioassay-guided fractionation. Their structures were identified by spectroscopic methods, and stereochemistry was confirmed by X-ray crystallographic analysis, CD spectral data, and Mosher's method. The isolates were evaluated for in vitro cytotoxic activity, and compounds 1 and 3 showed moderate cytotoxicity against lung (A549), breast (MDA-MB-231 and MCF7), and liver (HepG2) cancer cell lines.

Original language	English
Pages (from-to)	276-287
Number of pages	12
Journal	Phytochemistry
Volume	69
Issue number	1
DOIs	https://doi.org/10.1016/j.phytochem.2007.07.005
State	Published - 01 2008
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cytotoxicity
Euphorbiaceae
Gelomulides K-X
Gelonium aequoreum
ent-Abietane diterpenes

Access to Document

10.1016/j.phytochem.2007.07.005

Cite this

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title = "Cytotoxic ent-abietane diterpenes from Gelonium aequoreum",

abstract = "Seventeen ent-abietane diterpenes, including gelomulides K-X (1-14), and three known compounds, were isolated from a dichloromethane-soluble extract of Gelonium aequoreum through bioassay-guided fractionation. Their structures were identified by spectroscopic methods, and stereochemistry was confirmed by X-ray crystallographic analysis, CD spectral data, and Mosher's method. The isolates were evaluated for in vitro cytotoxic activity, and compounds 1 and 3 showed moderate cytotoxicity against lung (A549), breast (MDA-MB-231 and MCF7), and liver (HepG2) cancer cell lines.",

keywords = "Cytotoxicity, Euphorbiaceae, Gelomulides K-X, Gelonium aequoreum, ent-Abietane diterpenes",

author = "Lee, \{Chia Lin\} and Chang, \{Fang Rong\} and Hsieh, \{Pei Wen\} and Chiang, \{Michael Y.\} and Wu, \{Chin Chung\} and Huang, \{Zih You\} and Lan, \{Yu Hsuan\} and Mei Chen and Lee, \{Kuo Hsiung\} and Yen, \{Hsin Fu\} and Hung, \{Wen Chun\} and Wu, \{Yang Chang\}",

year = "2008",

month = jan,

doi = "10.1016/j.phytochem.2007.07.005",

language = "英语",

volume = "69",

pages = "276--287",

journal = "Phytochemistry",

issn = "0031-9422",

publisher = "Elsevier Ltd",

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TY - JOUR

T1 - Cytotoxic ent-abietane diterpenes from Gelonium aequoreum

AU - Lee, Chia Lin

AU - Chang, Fang Rong

AU - Hsieh, Pei Wen

AU - Chiang, Michael Y.

AU - Wu, Chin Chung

AU - Huang, Zih You

AU - Lan, Yu Hsuan

AU - Chen, Mei

AU - Lee, Kuo Hsiung

AU - Yen, Hsin Fu

AU - Hung, Wen Chun

AU - Wu, Yang Chang

PY - 2008/1

Y1 - 2008/1

N2 - Seventeen ent-abietane diterpenes, including gelomulides K-X (1-14), and three known compounds, were isolated from a dichloromethane-soluble extract of Gelonium aequoreum through bioassay-guided fractionation. Their structures were identified by spectroscopic methods, and stereochemistry was confirmed by X-ray crystallographic analysis, CD spectral data, and Mosher's method. The isolates were evaluated for in vitro cytotoxic activity, and compounds 1 and 3 showed moderate cytotoxicity against lung (A549), breast (MDA-MB-231 and MCF7), and liver (HepG2) cancer cell lines.

AB - Seventeen ent-abietane diterpenes, including gelomulides K-X (1-14), and three known compounds, were isolated from a dichloromethane-soluble extract of Gelonium aequoreum through bioassay-guided fractionation. Their structures were identified by spectroscopic methods, and stereochemistry was confirmed by X-ray crystallographic analysis, CD spectral data, and Mosher's method. The isolates were evaluated for in vitro cytotoxic activity, and compounds 1 and 3 showed moderate cytotoxicity against lung (A549), breast (MDA-MB-231 and MCF7), and liver (HepG2) cancer cell lines.

KW - Cytotoxicity

KW - Euphorbiaceae

KW - Gelomulides K-X

KW - Gelonium aequoreum

KW - ent-Abietane diterpenes

UR - https://www.scopus.com/pages/publications/37149040418

U2 - 10.1016/j.phytochem.2007.07.005

DO - 10.1016/j.phytochem.2007.07.005

M3 - 文章

C2 - 17714747

AN - SCOPUS:37149040418

SN - 0031-9422

VL - 69

SP - 276

EP - 287

JO - Phytochemistry

JF - Phytochemistry

IS - 1

ER -

Cytotoxic ent-abietane diterpenes from Gelonium aequoreum

Abstract

UN SDGs

Keywords

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