Cytotoxic triterpenoids from the leaves of Microtropis fokienensis

I. Hsiao Chen; Fang Rong Chang; Chin Chung Wu; Shu Li Chen; Pei Wen Hsieh; Hsin Fu Yen; Ying Chi Du; Yang Chang Wu

doi:10.1021/np060369n

Cytotoxic triterpenoids from the leaves of Microtropis fokienensis

I. Hsiao Chen
, Fang Rong Chang^*
, Chin Chung Wu
, Shu Li Chen
, Pei Wen Hsieh
, Hsin Fu Yen
, Ying Chi Du
, Yang Chang Wu

^*Corresponding author for this work

Kaohsiung Medical University
National Museum of Natural Science, Taiwan

Research output: Contribution to journal › Journal Article › peer-review

33 Scopus citations

Abstract

Five new triterpenoids, microfokienoxanes A-D (1-4) and 3β,28-dihydroxy-11α-methoxyurs-12-ene (5), were isolated and identified from the leaves of Microtropis fokienensis, along with nine known compounds. The structures of the new compounds were elucidated by spectroscopic methods. The compounds obtained in this investigation were evaluated against a small panel of human cancer cell lines for cytotoxicity. Only compounds 3 and 5 exhibited cytotoxicity (IC₅₀ ≤ 5 μg/mL) for one or more cell lines.

Original language	English
Pages (from-to)	1543-1546
Number of pages	4
Journal	Journal of Natural Products
Volume	69
Issue number	11
DOIs	https://doi.org/10.1021/np060369n
State	Published - 11 2006
Externally published	Yes

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1021/np060369n

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title = "Cytotoxic triterpenoids from the leaves of Microtropis fokienensis",

abstract = "Five new triterpenoids, microfokienoxanes A-D (1-4) and 3β,28-dihydroxy-11α-methoxyurs-12-ene (5), were isolated and identified from the leaves of Microtropis fokienensis, along with nine known compounds. The structures of the new compounds were elucidated by spectroscopic methods. The compounds obtained in this investigation were evaluated against a small panel of human cancer cell lines for cytotoxicity. Only compounds 3 and 5 exhibited cytotoxicity (IC50 ≤ 5 μg/mL) for one or more cell lines.",

author = "Chen, \{I. Hsiao\} and Chang, \{Fang Rong\} and Wu, \{Chin Chung\} and Chen, \{Shu Li\} and Hsieh, \{Pei Wen\} and Yen, \{Hsin Fu\} and Du, \{Ying Chi\} and Wu, \{Yang Chang\}",

year = "2006",

month = nov,

doi = "10.1021/np060369n",

language = "英语",

volume = "69",

pages = "1543--1546",

journal = "Journal of Natural Products",

issn = "0163-3864",

publisher = "American Chemical Society",

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}

TY - JOUR

T1 - Cytotoxic triterpenoids from the leaves of Microtropis fokienensis

AU - Chen, I. Hsiao

AU - Chang, Fang Rong

AU - Wu, Chin Chung

AU - Chen, Shu Li

AU - Hsieh, Pei Wen

AU - Yen, Hsin Fu

AU - Du, Ying Chi

AU - Wu, Yang Chang

PY - 2006/11

Y1 - 2006/11

N2 - Five new triterpenoids, microfokienoxanes A-D (1-4) and 3β,28-dihydroxy-11α-methoxyurs-12-ene (5), were isolated and identified from the leaves of Microtropis fokienensis, along with nine known compounds. The structures of the new compounds were elucidated by spectroscopic methods. The compounds obtained in this investigation were evaluated against a small panel of human cancer cell lines for cytotoxicity. Only compounds 3 and 5 exhibited cytotoxicity (IC50 ≤ 5 μg/mL) for one or more cell lines.

AB - Five new triterpenoids, microfokienoxanes A-D (1-4) and 3β,28-dihydroxy-11α-methoxyurs-12-ene (5), were isolated and identified from the leaves of Microtropis fokienensis, along with nine known compounds. The structures of the new compounds were elucidated by spectroscopic methods. The compounds obtained in this investigation were evaluated against a small panel of human cancer cell lines for cytotoxicity. Only compounds 3 and 5 exhibited cytotoxicity (IC50 ≤ 5 μg/mL) for one or more cell lines.

UR - https://www.scopus.com/pages/publications/33845931748

U2 - 10.1021/np060369n

DO - 10.1021/np060369n

M3 - 文章

C2 - 17125218

AN - SCOPUS:33845931748

SN - 0163-3864

VL - 69

SP - 1543

EP - 1546

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 11

ER -

Cytotoxic triterpenoids from the leaves of Microtropis fokienensis

Abstract

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