Danger signals, inflammasomes, and the intricate intracellular lives of chlamydiae

Matthew A. Pettengill, Ali Abdul-Sater, Robson Coutinho-Silva, David M. Ojcius*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations

Abstract

Chlamydiae are obligate intracellular bacterial pathogens, and as such are sensitive to alterations in the cellular physiology of their hosts. Chlamydial infections often cause pathologic consequences due to prolonged localized inflammation. Considerable advances have been made in the last few years regarding our understanding of how two key inflammation-associated signaling pathways influence the biology of Chlamydia infections: inflammation regulating purinergic signaling pathways significantly impact intracellular chlamydial development, and inflammasome activation modulates both chlamydial growth and infection mediated pro-inflammatory cytokine production. We review here elements of both pathways, presenting the latest developments contributing to our understanding of how chlamydial infections are influenced by inflammasomes and purinergic signaling.

Original languageEnglish
Pages (from-to)306-315
Number of pages10
JournalBiomedical Journal
Volume39
Issue number5
DOIs
StatePublished - 01 10 2016
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2016 Chang Gung University

Keywords

  • Chlamydia
  • Immunology
  • Infection
  • Inflammation
  • Innate immunity

Fingerprint

Dive into the research topics of 'Danger signals, inflammasomes, and the intricate intracellular lives of chlamydiae'. Together they form a unique fingerprint.

Cite this