Decorating protein nanospheres with lactoferrin enhances oral COX-2 inhibitor/herbal therapy of hepatocellular carcinoma

Mona A. Abdelmoneem, Mazen Mahmoud, Amira Zaky, Maged W. Helmy, Marwa Sallam, Jia You Fang, Kadria A. Elkhodairy, Ahmed O. Elzoghby*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

26 Scopus citations

Abstract

Aim: Lactoferrin (LF)-targeted gliadin nanoparticles (GL-NPs) were developed for targeted oral therapy of hepatocellular carcinoma. Materials & methods: Celecoxib and diosmin were incorporated in the hydrophobic matrix of GL-NPs whose surface was decorated with LF by electrostatic interaction for binding to asialoglycoprotein receptors overexpressed by liver cancer cells. Results: Targeted GL-NPs showed enhanced cytotoxic activity and increased cellular uptake in liver tumor cells compared with nontargeted NPs. Moreover, they demonstrated superior in vivo antitumor effects including reduction in the expression levels of tumor biomarkers and induction of caspase-mediated apoptosis. Ex vivo imaging of isolated organs exhibited extensive accumulation of NPs in livers more than other organs. Conclusion: LF-targeted GL-NPs could be considered as an efficient nanoplatform for targeted oral drug delivery for liver cancer therapy.

Original languageEnglish
Pages (from-to)2377-2395
Number of pages19
JournalNanomedicine
Volume13
Issue number19
DOIs
StatePublished - 01 10 2018

Bibliographical note

Publisher Copyright:
© 2018 Future Medicine Ltd.

Keywords

  • COX-2 inhibitors
  • Diosmin
  • Gliadin nanoparticles
  • Hepatocellular carcinoma
  • Lactoferrin-targeting
  • Oral delivery

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