Decorating protein nanospheres with lactoferrin enhances oral COX-2 inhibitor/herbal therapy of hepatocellular carcinoma

Mona A. Abdelmoneem; Mazen Mahmoud; Amira Zaky; Maged W. Helmy; Marwa Sallam; Jia You Fang; Kadria A. Elkhodairy; Ahmed O. Elzoghby

doi:10.2217/nnm-2018-0134

Decorating protein nanospheres with lactoferrin enhances oral COX-2 inhibitor/herbal therapy of hepatocellular carcinoma

Mona A. Abdelmoneem, Mazen Mahmoud, Amira Zaky, Maged W. Helmy, Marwa Sallam, Jia You Fang, Kadria A. Elkhodairy, Ahmed O. Elzoghby^*

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

30 Scopus citations

Abstract

Aim: Lactoferrin (LF)-targeted gliadin nanoparticles (GL-NPs) were developed for targeted oral therapy of hepatocellular carcinoma. Materials & methods: Celecoxib and diosmin were incorporated in the hydrophobic matrix of GL-NPs whose surface was decorated with LF by electrostatic interaction for binding to asialoglycoprotein receptors overexpressed by liver cancer cells. Results: Targeted GL-NPs showed enhanced cytotoxic activity and increased cellular uptake in liver tumor cells compared with nontargeted NPs. Moreover, they demonstrated superior in vivo antitumor effects including reduction in the expression levels of tumor biomarkers and induction of caspase-mediated apoptosis. Ex vivo imaging of isolated organs exhibited extensive accumulation of NPs in livers more than other organs. Conclusion: LF-targeted GL-NPs could be considered as an efficient nanoplatform for targeted oral drug delivery for liver cancer therapy.

Original language	English
Pages (from-to)	2377-2395
Number of pages	19
Journal	Nanomedicine
Volume	13
Issue number	19
DOIs	https://doi.org/10.2217/nnm-2018-0134
State	Published - 01 10 2018

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Publisher Copyright:
© 2018 Future Medicine Ltd.

Keywords

COX-2 inhibitors
Diosmin
Gliadin nanoparticles
Hepatocellular carcinoma
Lactoferrin-targeting
Oral delivery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2217/nnm-2018-0134

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@article{1767d345c90944a3ada9e93749d65e69,

title = "Decorating protein nanospheres with lactoferrin enhances oral COX-2 inhibitor/herbal therapy of hepatocellular carcinoma",

abstract = "Aim: Lactoferrin (LF)-targeted gliadin nanoparticles (GL-NPs) were developed for targeted oral therapy of hepatocellular carcinoma. Materials & methods: Celecoxib and diosmin were incorporated in the hydrophobic matrix of GL-NPs whose surface was decorated with LF by electrostatic interaction for binding to asialoglycoprotein receptors overexpressed by liver cancer cells. Results: Targeted GL-NPs showed enhanced cytotoxic activity and increased cellular uptake in liver tumor cells compared with nontargeted NPs. Moreover, they demonstrated superior in vivo antitumor effects including reduction in the expression levels of tumor biomarkers and induction of caspase-mediated apoptosis. Ex vivo imaging of isolated organs exhibited extensive accumulation of NPs in livers more than other organs. Conclusion: LF-targeted GL-NPs could be considered as an efficient nanoplatform for targeted oral drug delivery for liver cancer therapy.",

keywords = "COX-2 inhibitors, Diosmin, Gliadin nanoparticles, Hepatocellular carcinoma, Lactoferrin-targeting, Oral delivery",

author = "Abdelmoneem, {Mona A.} and Mazen Mahmoud and Amira Zaky and Helmy, {Maged W.} and Marwa Sallam and Fang, {Jia You} and Elkhodairy, {Kadria A.} and Elzoghby, {Ahmed O.}",

note = "Publisher Copyright: {\textcopyright} 2018 Future Medicine Ltd.",

year = "2018",

month = oct,

day = "1",

doi = "10.2217/nnm-2018-0134",

language = "英语",

volume = "13",

pages = "2377--2395",

journal = "Nanomedicine",

issn = "1743-5889",

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}

TY - JOUR

T1 - Decorating protein nanospheres with lactoferrin enhances oral COX-2 inhibitor/herbal therapy of hepatocellular carcinoma

AU - Abdelmoneem, Mona A.

AU - Mahmoud, Mazen

AU - Zaky, Amira

AU - Helmy, Maged W.

AU - Sallam, Marwa

AU - Fang, Jia You

AU - Elkhodairy, Kadria A.

AU - Elzoghby, Ahmed O.

PY - 2018/10/1

Y1 - 2018/10/1

N2 - Aim: Lactoferrin (LF)-targeted gliadin nanoparticles (GL-NPs) were developed for targeted oral therapy of hepatocellular carcinoma. Materials & methods: Celecoxib and diosmin were incorporated in the hydrophobic matrix of GL-NPs whose surface was decorated with LF by electrostatic interaction for binding to asialoglycoprotein receptors overexpressed by liver cancer cells. Results: Targeted GL-NPs showed enhanced cytotoxic activity and increased cellular uptake in liver tumor cells compared with nontargeted NPs. Moreover, they demonstrated superior in vivo antitumor effects including reduction in the expression levels of tumor biomarkers and induction of caspase-mediated apoptosis. Ex vivo imaging of isolated organs exhibited extensive accumulation of NPs in livers more than other organs. Conclusion: LF-targeted GL-NPs could be considered as an efficient nanoplatform for targeted oral drug delivery for liver cancer therapy.

AB - Aim: Lactoferrin (LF)-targeted gliadin nanoparticles (GL-NPs) were developed for targeted oral therapy of hepatocellular carcinoma. Materials & methods: Celecoxib and diosmin were incorporated in the hydrophobic matrix of GL-NPs whose surface was decorated with LF by electrostatic interaction for binding to asialoglycoprotein receptors overexpressed by liver cancer cells. Results: Targeted GL-NPs showed enhanced cytotoxic activity and increased cellular uptake in liver tumor cells compared with nontargeted NPs. Moreover, they demonstrated superior in vivo antitumor effects including reduction in the expression levels of tumor biomarkers and induction of caspase-mediated apoptosis. Ex vivo imaging of isolated organs exhibited extensive accumulation of NPs in livers more than other organs. Conclusion: LF-targeted GL-NPs could be considered as an efficient nanoplatform for targeted oral drug delivery for liver cancer therapy.

KW - COX-2 inhibitors

KW - Diosmin

KW - Gliadin nanoparticles

KW - Hepatocellular carcinoma

KW - Lactoferrin-targeting

KW - Oral delivery

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U2 - 10.2217/nnm-2018-0134

DO - 10.2217/nnm-2018-0134

M3 - 文章

C2 - 30346255

AN - SCOPUS:85055905781

SN - 1743-5889

VL - 13

SP - 2377

EP - 2395

JO - Nanomedicine

JF - Nanomedicine

IS - 19

ER -

Decorating protein nanospheres with lactoferrin enhances oral COX-2 inhibitor/herbal therapy of hepatocellular carcinoma

Abstract

Bibliographical note

Keywords

UN SDGs

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