TY - JOUR
T1 - Dectin-1 escape by fungal dimorphism
AU - Heinsbroek, Sigrid E.M.
AU - Brown, Gordon D.
AU - Gordon, Siamon
PY - 2005/7
Y1 - 2005/7
N2 - Candida albicans, a medically important fungus, exists primarily as yeast and filamentous forms. Its cell wall is rich in β-glucans, which are recognized by a lectin-like innate immune receptor, Dectin-1. A recent study shows that exposure of glucan, by yeasts but not filaments, determines Dectin-1-dependent uptake by macrophages, and thus represents a novel immune evasion mechanism. Here, we discuss the insights these results provide in relation to macrophage interactions with C. albicans and pathogen entry.
AB - Candida albicans, a medically important fungus, exists primarily as yeast and filamentous forms. Its cell wall is rich in β-glucans, which are recognized by a lectin-like innate immune receptor, Dectin-1. A recent study shows that exposure of glucan, by yeasts but not filaments, determines Dectin-1-dependent uptake by macrophages, and thus represents a novel immune evasion mechanism. Here, we discuss the insights these results provide in relation to macrophage interactions with C. albicans and pathogen entry.
UR - http://www.scopus.com/inward/record.url?scp=20644446062&partnerID=8YFLogxK
U2 - 10.1016/j.it.2005.05.005
DO - 10.1016/j.it.2005.05.005
M3 - 短篇评述
C2 - 15922664
AN - SCOPUS:20644446062
SN - 1471-4906
VL - 26
SP - 352
EP - 354
JO - Trends in Immunology
JF - Trends in Immunology
IS - 7
ER -