Dehydroepiandrosterone induces growth arrest of hepatoma cells via alteration of mitochondrial gene expression and function

Hung Yao Ho*, Mei Ling Cheng, Hsin Yu Chiu, Shiue Fen Weng, Daniel Tsun Yee Chiu

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

28 Scopus citations

Abstract

DHEA is known to have anti-proliferative effect. The mechanism is not completely understood. We investigated the mechanism underlying DHEA-induced growth arrest of hepatoma cells. Growth inhibition was associated with increased G6PD activity, and insensitive to reversal by mevalonate. Thus, DHEA does not act via inhibition of G6PD and HMGR. Instead, growth stagnation was accompanied by reduced expression of nucleus-encoded mitochondrial genes; morphological and functional alterations of mitochondria; and depletion of intracellular ATP. Conversely, pyruvate supplementation alleviated DHEA-induced growth inhibition. It is likely that DHEA suppresses cell growth by altering mitochondrial gene expression, morphology and functions.

Original languageEnglish
Pages (from-to)969-977
Number of pages9
JournalInternational Journal of Oncology
Volume33
Issue number5
DOIs
StatePublished - 2008

Keywords

  • Hepatoma
  • Mitochondrion
  • Steroid

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