Delta-Frequency Augmentation and Synchronization in Seizure Discharges and Telencephalic Transmission

Ping Chou, Guan Hsun Wang, Shu Wei Hsueh, Ya Chin Yang*, Chung Chin Kuo*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

12 Scopus citations


Epileptic seizures constitute a common neurological disease primarily diagnosed by characteristic rhythms or waves in the local field potentials (LFPs) of cerebral cortices or electroencephalograms. With a basolateral amygdala (BLA) kindling model, we found that the dominant frequency of BLA oscillations is in the delta range (1–5 Hz) in both normal and seizure conditions. Multi-unit discharges are increased with higher seizure staging but remain phase-locked to the delta waves in LFPs. Also, the change in synchrony precedes and outlasts the changes in discharging units as well as behavioral seizures. One short train of stimuli readily drives the pyramidal-inhibitory neuronal networks in BLA slices into prolonged reverberating activities, where the burst and interburst intervals may concurrently set a “natural wavelength” for delta frequencies. Seizures thus could be viewed as erroneous temporospatial continuums to normal oscillations in a system with a built-in synchronizing and resonating nature for information relay.

Original languageEnglish
Article number101666
Issue number11
StatePublished - 20 11 2020

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  • Behavioral Neuroscience
  • Systems Neuroscience
  • Techniques in Neuroscience


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