Dendritic Cell Therapy in Composite Tissue Allotransplantation

A. W. Thomson; J. M. Sacks; Y. R. Kuo; R. Ikeguchi; E. K. Horibe; J. Unadkat; M. G. Solari; M. Feili-Hariri; W. P.A. Lee

doi:10.1016/j.transproceed.2009.01.011

Dendritic Cell Therapy in Composite Tissue Allotransplantation

A. W. Thomson^*, J. M. Sacks, Y. R. Kuo, R. Ikeguchi, E. K. Horibe, J. Unadkat, M. G. Solari, M. Feili-Hariri, W. P.A. Lee

^*Corresponding author for this work

University of Pittsburgh

Research output: Contribution to journal › Journal Article › peer-review

7 Scopus citations

Abstract

Dendritic cells (DCs) are bone marrow-derived, professional antigen-presenting cells, with inherent tolerogenic function. The ability of immature or maturation-resistant DCs to regulate alloantigen-specific T-cell responses and to promote tolerance induction has been well demonstrated in organ and bone marrow transplantation. Recent data suggest that DCs can also promote long-term survival of composite tissue allografts in the absence of continued immunosuppressive drug therapy.

Original language	English
Pages (from-to)	537-538
Number of pages	2
Journal	Transplantation Proceedings
Volume	41
Issue number	2
DOIs	https://doi.org/10.1016/j.transproceed.2009.01.011
State	Published - 03 2009
Externally published	Yes

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10.1016/j.transproceed.2009.01.011

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title = "Dendritic Cell Therapy in Composite Tissue Allotransplantation",

abstract = "Dendritic cells (DCs) are bone marrow-derived, professional antigen-presenting cells, with inherent tolerogenic function. The ability of immature or maturation-resistant DCs to regulate alloantigen-specific T-cell responses and to promote tolerance induction has been well demonstrated in organ and bone marrow transplantation. Recent data suggest that DCs can also promote long-term survival of composite tissue allografts in the absence of continued immunosuppressive drug therapy.",

author = "Thomson, {A. W.} and Sacks, {J. M.} and Kuo, {Y. R.} and R. Ikeguchi and Horibe, {E. K.} and J. Unadkat and Solari, {M. G.} and M. Feili-Hariri and Lee, {W. P.A.}",

year = "2009",

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AU - Thomson, A. W.

AU - Sacks, J. M.

AU - Kuo, Y. R.

AU - Ikeguchi, R.

AU - Horibe, E. K.

AU - Unadkat, J.

AU - Solari, M. G.

AU - Feili-Hariri, M.

AU - Lee, W. P.A.

PY - 2009/3

Y1 - 2009/3

N2 - Dendritic cells (DCs) are bone marrow-derived, professional antigen-presenting cells, with inherent tolerogenic function. The ability of immature or maturation-resistant DCs to regulate alloantigen-specific T-cell responses and to promote tolerance induction has been well demonstrated in organ and bone marrow transplantation. Recent data suggest that DCs can also promote long-term survival of composite tissue allografts in the absence of continued immunosuppressive drug therapy.

AB - Dendritic cells (DCs) are bone marrow-derived, professional antigen-presenting cells, with inherent tolerogenic function. The ability of immature or maturation-resistant DCs to regulate alloantigen-specific T-cell responses and to promote tolerance induction has been well demonstrated in organ and bone marrow transplantation. Recent data suggest that DCs can also promote long-term survival of composite tissue allografts in the absence of continued immunosuppressive drug therapy.

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U2 - 10.1016/j.transproceed.2009.01.011

DO - 10.1016/j.transproceed.2009.01.011

M3 - 文章

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AN - SCOPUS:62849108696

SN - 0041-1345

VL - 41

SP - 537

EP - 538

JO - Transplantation Proceedings

JF - Transplantation Proceedings

IS - 2

ER -

Dendritic Cell Therapy in Composite Tissue Allotransplantation

Abstract

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