Design and synthesis of glyco-peptides as anti-cancer agents targeting thrombin-protease activated receptor-1 interaction

Yu Hsuan Chang; Jen Chine Wu; Hui Ming Yu; Hua Ting Hsu; Ying Ta Wu; Alice Lin Tsing Yu; Cheng Der Tony Yu; Chi Huey Wong

doi:10.1039/d0cc01240h

Design and synthesis of glyco-peptides as anti-cancer agents targeting thrombin-protease activated receptor-1 interaction

Yu Hsuan Chang, Jen Chine Wu, Hui Ming Yu, Hua Ting Hsu, Ying Ta Wu, Alice Lin Tsing Yu, Cheng Der Tony Yu, Chi Huey Wong^*

^*Corresponding author for this work

Graduate Institute of Biomedical Sciences

Research output: Contribution to journal › Journal Article › peer-review

4 Scopus citations

Abstract

Thrombin activates protease-activated receptor-1 (PAR-1) through binding to exosite I and the active site to promote tumor growth. We have developed a new class of anti-cancer glyco-peptides to target exosite I selectively without affecting the active-site-mediated coagulation activity and showed the importance of glycans for the stability and anti-cancer activity of the glyco-peptides.

Original language	English
Pages (from-to)	5827-5830
Number of pages	4
Journal	Chemical Communications
Volume	56
Issue number	43
DOIs	https://doi.org/10.1039/d0cc01240h
State	Published - 28 05 2020

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© The Royal Society of Chemistry 2020.

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title = "Design and synthesis of glyco-peptides as anti-cancer agents targeting thrombin-protease activated receptor-1 interaction",

abstract = "Thrombin activates protease-activated receptor-1 (PAR-1) through binding to exosite I and the active site to promote tumor growth. We have developed a new class of anti-cancer glyco-peptides to target exosite I selectively without affecting the active-site-mediated coagulation activity and showed the importance of glycans for the stability and anti-cancer activity of the glyco-peptides.",

author = "Chang, \{Yu Hsuan\} and Wu, \{Jen Chine\} and Yu, \{Hui Ming\} and Hsu, \{Hua Ting\} and Wu, \{Ying Ta\} and Yu, \{Alice Lin Tsing\} and Yu, \{Cheng Der Tony\} and Wong, \{Chi Huey\}",

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year = "2020",

month = may,

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doi = "10.1039/d0cc01240h",

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T1 - Design and synthesis of glyco-peptides as anti-cancer agents targeting thrombin-protease activated receptor-1 interaction

AU - Chang, Yu Hsuan

AU - Wu, Jen Chine

AU - Yu, Hui Ming

AU - Hsu, Hua Ting

AU - Wu, Ying Ta

AU - Yu, Alice Lin Tsing

AU - Yu, Cheng Der Tony

AU - Wong, Chi Huey

PY - 2020/5/28

Y1 - 2020/5/28

N2 - Thrombin activates protease-activated receptor-1 (PAR-1) through binding to exosite I and the active site to promote tumor growth. We have developed a new class of anti-cancer glyco-peptides to target exosite I selectively without affecting the active-site-mediated coagulation activity and showed the importance of glycans for the stability and anti-cancer activity of the glyco-peptides.

AB - Thrombin activates protease-activated receptor-1 (PAR-1) through binding to exosite I and the active site to promote tumor growth. We have developed a new class of anti-cancer glyco-peptides to target exosite I selectively without affecting the active-site-mediated coagulation activity and showed the importance of glycans for the stability and anti-cancer activity of the glyco-peptides.

UR - https://www.scopus.com/pages/publications/85085599259

U2 - 10.1039/d0cc01240h

DO - 10.1039/d0cc01240h

M3 - 文章

C2 - 32329494

AN - SCOPUS:85085599259

SN - 1359-7345

VL - 56

SP - 5827

EP - 5830

JO - Chemical Communications

JF - Chemical Communications

IS - 43

ER -

Design and synthesis of glyco-peptides as anti-cancer agents targeting thrombin-protease activated receptor-1 interaction

Abstract

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