Detection of B cell lymphoma involvement in T cell-rich serous fluid by immunoglobulin gene rearrangement: A report of 2 cases

  • Hung Chang
  • , Chien Feng Sun*
  • *Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

2 Scopus citations

Abstract

Background: Cytology, flow cytometry and gene rearrangement studies are methods to detect lymphoma involvement of body fluid. The cytology of the effusion is equivocal for lymphoma involvement. Cases: We report 2 cases of diffuse large B cell lymphoma with massive lymphocyte predominant serous fluid, ascites in one case and pleural effusion in the other. Immunophenotypic analysis by flow cytometry showed that lymphoid cells express only T cell markers. Lymphoma involvement of effusion was confirmed by immunoglobulin gene rearrangement detected by polymerase chain reaction. Conclusion: Our case demonstrated the value of gene rearrangement study in establishing diagnosis of equivocal cases.

Original languageEnglish
Pages (from-to)231-234
Number of pages4
JournalActa Cytologica
Volume52
Issue number2
DOIs
StatePublished - 2008
Externally publishedYes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

Keywords

  • Ascites
  • Lymphoma
  • Pleural effusion

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