Detection of real sample DNA at a cadmium sulfide - chitosan/gelatin modified electrode

Ying Li, Wan Chun Chen, Shen Ming Chen*, Bih Show Lou, M. Ajmal Ali, Fahad M.A. Al-Hemaid

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

14 Scopus citations


Cadmium sulfide (CdS) was combined with chitosan (Chi) and gelatin (Gel) to prepare a CdS Chi/. Gel modified electrode. Chi exhibits a large positive charge density and was to provide a uniform of CdS surface. Gel exhibits high mechanical strength and low toxicity toward mammalian cells, and is non-antigenic biopolymer. CdS Chi exhibits a lower contact angle than that of bare CdS, indicating that the hydrophilicity of the sample surface had increased. Electrochemical impedance spectroscopy (EIS) was used to determine diffusion coefficients and to characterize the electron transfer kinetics during the redox reactions. The surface morphologies of CdS Chi and Gel were characterized using scanning electron microscopy (SEM) and atomic force microscopy (AFM). Differential pulse voltammetry (DPV) was used to detect the analytes. DPV not only increased the linear range of the electrocatalytic current, but also lowered the overpotential for oxidation interference in the measurements. The CdS electrode exhibited a enhanced electrocatalytic activity toward the analytes evaluated in this study. The presence of Gel enhanced the loading and stability of the electrode. The fabricated electrode was successfully used for the simultaneous electrochemical oxidation of guanine (G) and adenine (A).

Original languageEnglish
Pages (from-to)85-91
Number of pages7
JournalColloids and Surfaces B: Biointerfaces
StatePublished - 01 01 2014


  • Adenine (A)
  • Cadmium sulfide (CdS)
  • Chitosan (Chi)
  • Gelatin (Gel)
  • Guanine (G)
  • Modified electrodes


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