Determining malnutrition assessment criteria to predict one-year mortality for locally advanced head and neck cancer patients undergoing concurrent chemoradiotherapy

Hang Huong Ling, Kun Yun Yeh, Shu Hang Ng, Cheng Hsu Wang, Chien Hong Lai, Tsung Han Wu, Pei Hung Chang, Wen Chi Chou, Fang Ping Chen, Yu Ching Lin*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

7 Scopus citations

Abstract

Study on the impact of pretreatment malnutrition on treatment outcomes in locally advanced head and neck cancer (LAHNC) patients is still lacking. We prospectively collected various malnutrition assessment methods including nutrition indexes, inflammatory biomarkers, and lean body mass index (LBMI) data before treatments. The one year mortality rate was assessed, and the factors associated with this outcome were investigated. Furthermore, the association between malnutrition assessment methods was examined. A total of 113 patients were enrolled. By prognostic stratification based on the prognostic nutritional index (PNI) and platelet-to-lymphocyte ratio (PLR) combination, the low PNI/high PLR group had highest and the high PNI/low PLR group had the lowest mortality rate. Furthermore, the PNI was positively correlated with the LBMI, and the PLR was inversely correlated with the LBMI. PNI and PLR were found to be independent prognostic factors of one year mortality and also associated with the loss of muscle.

Original languageEnglish
Article number836
JournalNutrients
Volume12
Issue number3
DOIs
StatePublished - 03 2020

Bibliographical note

Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

  • Biomarkers
  • Head and neck cancer
  • Muscle mass
  • Nutrition
  • Survival

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