Development for wound dressing based on blended chitosan and gelatin hydrogels

I. Hao Chen; Ching Ming Chien; Chun Ting Wang; Chih Ling Huang; Chih Kuang Wang; Yur Ren Kuo

doi:10.4028/www.scientific.net/KEM.765.119

Development for wound dressing based on blended chitosan and gelatin hydrogels

I. Hao Chen, Ching Ming Chien, Chun Ting Wang, Chih Ling Huang^*, Chih Kuang Wang, Yur Ren Kuo

^*Corresponding author for this work

Kaohsiung Medical University

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Scopus citations

Abstract

Chitosan and gelatin are potential wound dressing materials. However, chitosan takes too much time to degrade and gelatin degrades too fast. As a result, chitosan and gelatin are blended to adjust their degradation rate. The degree of degradation test by means of weight loss and thermogravimetric analyzer after being incubated with lysozyme, which is a common enzyme in body fluid. Optical microscopy was used to observe the materials morphology after immersed in water. Finally, fibroblast cells were cultured with various material extracts to examine cell adhesion in vitro. Cell adhesion tests showed there are no negative effect on cells. Therefore, there is no cell toxicity of chitosan on cells. Chitosan and gelatin can be promising wound dressing raw materials in future.

Original language	English
Title of host publication	Advanced Materials Research VII
Editors	Serge Zhuiykov
Publisher	Trans Tech Publications Ltd
Pages	119-123
Number of pages	5
ISBN (Print)	9783035712308
DOIs	https://doi.org/10.4028/www.scientific.net/KEM.765.119
State	Published - 2018
Externally published	Yes
Event	8th International Conference on Advanced Materials Research, ICAMR 2018 - Fukuoka, Japan Duration: 20 01 2018 → 22 01 2018

Publication series

Name	Key Engineering Materials
Volume	765 KEM
ISSN (Print)	1013-9826
ISSN (Electronic)	1662-9795

Conference

Conference	8th International Conference on Advanced Materials Research, ICAMR 2018
Country/Territory	Japan
City	Fukuoka
Period	20/01/18 → 22/01/18

Bibliographical note

Publisher Copyright:
© 2018 Trans Tech Publications, Switzerland.

Keywords

Chitosan
Gelatin
Wound dressing

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10.4028/www.scientific.net/KEM.765.119

Cite this

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title = "Development for wound dressing based on blended chitosan and gelatin hydrogels",

abstract = "Chitosan and gelatin are potential wound dressing materials. However, chitosan takes too much time to degrade and gelatin degrades too fast. As a result, chitosan and gelatin are blended to adjust their degradation rate. The degree of degradation test by means of weight loss and thermogravimetric analyzer after being incubated with lysozyme, which is a common enzyme in body fluid. Optical microscopy was used to observe the materials morphology after immersed in water. Finally, fibroblast cells were cultured with various material extracts to examine cell adhesion in vitro. Cell adhesion tests showed there are no negative effect on cells. Therefore, there is no cell toxicity of chitosan on cells. Chitosan and gelatin can be promising wound dressing raw materials in future.",

keywords = "Chitosan, Gelatin, Wound dressing",

author = "Chen, {I. Hao} and Chien, {Ching Ming} and Wang, {Chun Ting} and Huang, {Chih Ling} and Wang, {Chih Kuang} and Kuo, {Yur Ren}",

note = "Publisher Copyright: {\textcopyright} 2018 Trans Tech Publications, Switzerland.; 8th International Conference on Advanced Materials Research, ICAMR 2018 ; Conference date: 20-01-2018 Through 22-01-2018",

year = "2018",

doi = "10.4028/www.scientific.net/KEM.765.119",

language = "英语",

isbn = "9783035712308",

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publisher = "Trans Tech Publications Ltd",

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Chen, IH, Chien, CM, Wang, CT, Huang, CL, Wang, CK & Kuo, YR 2018, Development for wound dressing based on blended chitosan and gelatin hydrogels. in S Zhuiykov (ed.), Advanced Materials Research VII. Key Engineering Materials, vol. 765 KEM, Trans Tech Publications Ltd, pp. 119-123, 8th International Conference on Advanced Materials Research, ICAMR 2018, Fukuoka, Japan, 20/01/18. https://doi.org/10.4028/www.scientific.net/KEM.765.119

Development for wound dressing based on blended chitosan and gelatin hydrogels. / Chen, I. Hao; Chien, Ching Ming; Wang, Chun Ting et al.
Advanced Materials Research VII. ed. / Serge Zhuiykov. Trans Tech Publications Ltd, 2018. p. 119-123 (Key Engineering Materials; Vol. 765 KEM).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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T1 - Development for wound dressing based on blended chitosan and gelatin hydrogels

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AU - Chien, Ching Ming

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AU - Huang, Chih Ling

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AU - Kuo, Yur Ren

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N2 - Chitosan and gelatin are potential wound dressing materials. However, chitosan takes too much time to degrade and gelatin degrades too fast. As a result, chitosan and gelatin are blended to adjust their degradation rate. The degree of degradation test by means of weight loss and thermogravimetric analyzer after being incubated with lysozyme, which is a common enzyme in body fluid. Optical microscopy was used to observe the materials morphology after immersed in water. Finally, fibroblast cells were cultured with various material extracts to examine cell adhesion in vitro. Cell adhesion tests showed there are no negative effect on cells. Therefore, there is no cell toxicity of chitosan on cells. Chitosan and gelatin can be promising wound dressing raw materials in future.

AB - Chitosan and gelatin are potential wound dressing materials. However, chitosan takes too much time to degrade and gelatin degrades too fast. As a result, chitosan and gelatin are blended to adjust their degradation rate. The degree of degradation test by means of weight loss and thermogravimetric analyzer after being incubated with lysozyme, which is a common enzyme in body fluid. Optical microscopy was used to observe the materials morphology after immersed in water. Finally, fibroblast cells were cultured with various material extracts to examine cell adhesion in vitro. Cell adhesion tests showed there are no negative effect on cells. Therefore, there is no cell toxicity of chitosan on cells. Chitosan and gelatin can be promising wound dressing raw materials in future.

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KW - Gelatin

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Development for wound dressing based on blended chitosan and gelatin hydrogels

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Bibliographical note

Keywords

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