Development of a pixelated detector for clinical positron and single-photon molecular imaging

Hsin Ching Liang, Meei Ling Jan*, Jenn Lung Su

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

6 Scopus citations

Abstract

An imaging detector as a base unit for a gamma camera for dual-modality (positron and single-photon) molecular imaging is developed in this study. The imaging detector is constructed using scintillation material lutetium yttrium oxyorthosilicate (LYSO) and a position-sensitive photo-multiplier tube. Performance indices for dual-modality imaging applications are measured and the detectors feasibility is evaluated. Since LYSO exhibits spontaneous radiation, the practicality of the unit for single-photon imaging is evaluated. The results show that mean pixel widths of 0.6 and 0.8 mm and energy resolutions of 10% and 15% are achieved for 511 keV and 122 keV gammas, respectively, with a crystal pixel size of 1.5 mm. This pixel size is shown to be an engineering limit for meeting the requirement of the two imaging modalities. The background count rate from spontaneous radiation of 69 counts per second (cps) is less than 1/10 the size of the recorded signals in pinhole-collimated imaging. It is thus concluded that the proposed LYSO-based detector unit can be applied to dual-modality molecular imaging for clinical use with outstanding performance.

Original languageEnglish
Pages (from-to)373-380
Number of pages8
JournalJournal of Medical and Biological Engineering
Volume32
Issue number5
DOIs
StatePublished - 2012
Externally publishedYes

Keywords

  • Dual-modality imaging
  • Lutetium yttrium oxyortho silicate (LYSO)
  • Pixelated imaging detector

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