Development of antioxidants as anti - atherosclerotic agents

Ming Shi Shiao*, Li Ling Chu, Elaine Lin, Lily Chiu

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

Abstract

Antioxidants capable of inhibiting LDL oxidation may reduce atherosclerosis. Many Chinese herbs on blood stasis contain antioxidants to inhibit LDL oxidation. Caffeic acid phenethyl ester and several caffeic acid - containing analogues more potent than probucol have been identified. We conclude that lipophilic antioxidants which can incorporate into LDL with their antioxidative functionalities being exposed ahead of the bis - allylic sites of PUFA in LDL are most favorable.

Original languageEnglish
Pages (from-to)12-15
Number of pages4
JournalChinese Journal of Organic Chemistry
Volume17
Issue number1
StatePublished - 1997
Externally publishedYes

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