Development of antioxidants as anti - atherosclerotic agents

Ming Shi Shiao*, Li Ling Chu, Elaine Lin, Lily Chiu

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review


Antioxidants capable of inhibiting LDL oxidation may reduce atherosclerosis. Many Chinese herbs on blood stasis contain antioxidants to inhibit LDL oxidation. Caffeic acid phenethyl ester and several caffeic acid - containing analogues more potent than probucol have been identified. We conclude that lipophilic antioxidants which can incorporate into LDL with their antioxidative functionalities being exposed ahead of the bis - allylic sites of PUFA in LDL are most favorable.

Original languageEnglish
Pages (from-to)12-15
Number of pages4
JournalChinese Journal of Organic Chemistry
Issue number1
StatePublished - 1997
Externally publishedYes


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