Development of carbapenem resistance during therapy for non-typhoid Salmonella infection

L. H. Su; T. L. Wu; C. H. Chiu

doi:10.1111/j.1469-0691.2012.03767.x

Development of carbapenem resistance during therapy for non-typhoid Salmonella infection

L. H. Su, T. L. Wu, C. H. Chiu^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

25 Scopus citations

Abstract

Multidrug-resistant Salmonella infection is a global problem, and carbapenems may represent the last therapeutic choice. We report a case of infection caused by ceftriaxone-resistant and ciprofloxacin-resistant Salmonella enterica serotype Typhimurium. A bla_CMY-2-containing Tn6092, located on a self-transferable IncI1 plasmid, was found in all isolates derived from the patient. During ertapenem treatment, the strain developed carbapenem resistance. Apart from the OmpD deficiency found in all isolates, the strain further developed OmpC deficiency through a single gene mutation, and became carbapenem-resistant. Salmonella appears to be very plastic in developing antimicrobial resistance. Care must be taken by physicians when treating multidrug-resistant Salmonella infection.

Original language	English
Pages (from-to)	E91-E94
Journal	Clinical Microbiology and Infection
Volume	18
Issue number	4
DOIs	https://doi.org/10.1111/j.1469-0691.2012.03767.x
State	Published - 04 2012
Externally published	Yes

Keywords

Carbapenem resistance
IncI1 plasmid
Non-typhoid Salmonella
Porin loss
Tn6092

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1469-0691.2012.03767.x

Cite this

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title = "Development of carbapenem resistance during therapy for non-typhoid Salmonella infection",

abstract = "Multidrug-resistant Salmonella infection is a global problem, and carbapenems may represent the last therapeutic choice. We report a case of infection caused by ceftriaxone-resistant and ciprofloxacin-resistant Salmonella enterica serotype Typhimurium. A blaCMY-2-containing Tn6092, located on a self-transferable IncI1 plasmid, was found in all isolates derived from the patient. During ertapenem treatment, the strain developed carbapenem resistance. Apart from the OmpD deficiency found in all isolates, the strain further developed OmpC deficiency through a single gene mutation, and became carbapenem-resistant. Salmonella appears to be very plastic in developing antimicrobial resistance. Care must be taken by physicians when treating multidrug-resistant Salmonella infection.",

keywords = "Carbapenem resistance, IncI1 plasmid, Non-typhoid Salmonella, Porin loss, Tn6092",

author = "Su, {L. H.} and Wu, {T. L.} and Chiu, {C. H.}",

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T1 - Development of carbapenem resistance during therapy for non-typhoid Salmonella infection

AU - Su, L. H.

AU - Wu, T. L.

AU - Chiu, C. H.

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N2 - Multidrug-resistant Salmonella infection is a global problem, and carbapenems may represent the last therapeutic choice. We report a case of infection caused by ceftriaxone-resistant and ciprofloxacin-resistant Salmonella enterica serotype Typhimurium. A blaCMY-2-containing Tn6092, located on a self-transferable IncI1 plasmid, was found in all isolates derived from the patient. During ertapenem treatment, the strain developed carbapenem resistance. Apart from the OmpD deficiency found in all isolates, the strain further developed OmpC deficiency through a single gene mutation, and became carbapenem-resistant. Salmonella appears to be very plastic in developing antimicrobial resistance. Care must be taken by physicians when treating multidrug-resistant Salmonella infection.

AB - Multidrug-resistant Salmonella infection is a global problem, and carbapenems may represent the last therapeutic choice. We report a case of infection caused by ceftriaxone-resistant and ciprofloxacin-resistant Salmonella enterica serotype Typhimurium. A blaCMY-2-containing Tn6092, located on a self-transferable IncI1 plasmid, was found in all isolates derived from the patient. During ertapenem treatment, the strain developed carbapenem resistance. Apart from the OmpD deficiency found in all isolates, the strain further developed OmpC deficiency through a single gene mutation, and became carbapenem-resistant. Salmonella appears to be very plastic in developing antimicrobial resistance. Care must be taken by physicians when treating multidrug-resistant Salmonella infection.

KW - Carbapenem resistance

KW - IncI1 plasmid

KW - Non-typhoid Salmonella

KW - Porin loss

KW - Tn6092

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U2 - 10.1111/j.1469-0691.2012.03767.x

DO - 10.1111/j.1469-0691.2012.03767.x

M3 - 文章

AN - SCOPUS:84858703804

SN - 1198-743X

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JO - Clinical Microbiology and Infection

JF - Clinical Microbiology and Infection

IS - 4

ER -

Development of carbapenem resistance during therapy for non-typhoid Salmonella infection

Abstract

Keywords

UN SDGs

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