Development of carbapenem resistance during therapy for non-typhoid Salmonella infection

L. H. Su, T. L. Wu, C. H. Chiu*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

25 Scopus citations


Multidrug-resistant Salmonella infection is a global problem, and carbapenems may represent the last therapeutic choice. We report a case of infection caused by ceftriaxone-resistant and ciprofloxacin-resistant Salmonella enterica serotype Typhimurium. A blaCMY-2-containing Tn6092, located on a self-transferable IncI1 plasmid, was found in all isolates derived from the patient. During ertapenem treatment, the strain developed carbapenem resistance. Apart from the OmpD deficiency found in all isolates, the strain further developed OmpC deficiency through a single gene mutation, and became carbapenem-resistant. Salmonella appears to be very plastic in developing antimicrobial resistance. Care must be taken by physicians when treating multidrug-resistant Salmonella infection.

Original languageEnglish
Pages (from-to)E91-E94
JournalClinical Microbiology and Infection
Issue number4
StatePublished - 04 2012
Externally publishedYes


  • Carbapenem resistance
  • IncI1 plasmid
  • Non-typhoid Salmonella
  • Porin loss
  • Tn6092


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