Development of fabrication and detection system for centrifugal force and thermal management biochip

Ming Yih Lee; Chen Ya Wang; Hung Chia Lin; Hung Wei Chiang; Liang Shiuan Su; Tsung Wei Chang

doi:10.1109/ICMECH.2005.1529382

Development of fabrication and detection system for centrifugal force and thermal management biochip

Ming Yih Lee^*, Chen Ya Wang, Hung Chia Lin, Hung Wei Chiang, Liang Shiuan Su, Tsung Wei Chang

^*Corresponding author for this work

Department of Biomedical Engineering

Chang Gung University

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

The development of Micro-Electro-Mechanical Systems (MEMS) advances the success of microfabricated devices, and microfabricated devices offer many specific platforms that can integrate a laboratory on a chip and manage micro biochemical reaction analysis. Nevertheless, most microfabricated devices, especially in biochip design, are depending on semi-conductor or LIGA process so that the configuration of devices is complex and money-consumed. Furthermore, miniaturization in nano-scale isn't always significant in bio-medical reactions. Thus, the aim of our research is to develop a fabrication and detection system of centrifugal-force and thermal management biochip, which will improve the complex pumps and valves designed by semi-conductor application in lab-on-a-chip, and it saves time and money in the comparison of traditional lab technology. Our system uses the software-SolidWorks and computer numerical control (CNC) machine to design microfluidic patterns, the heat pressure machine with feedback control of temperature sensor to design the hermetically sealed biochip, and the centrifugal machine with server frequency conversion motor to lead sample mobility by centrifugal force instead of pumps and valves. The hardware of this system includes three parts: centrifugal machine, heat pressure machine, and microfluidic fabrication; the application of the biochip is to detect clinical and medicine bio-reactions. Our "fabrication and detection system for centrifugal-force and thermal management biochip" developed in this study is a on-table facility and can use in several areas of medical and clinical examinations, it can also combine with polymerase chain reaction (PCR) by adding temperature controlling procedure in the future.

Original language	English
Title of host publication	Proceedings of the 2005 IEEE International Conference on Mechatronics, ICM '05
Pages	903-908
Number of pages	6
DOIs	https://doi.org/10.1109/ICMECH.2005.1529382
State	Published - 2005
Event	2005 IEEE International Conference on Mechatronics, ICM '05 - Taipei, Taiwan Duration: 10 07 2005 → 12 07 2005

Publication series

Name	Proceedings of the 2005 IEEE International Conference on Mechatronics, ICM '05
Volume	2005

Conference

Conference	2005 IEEE International Conference on Mechatronics, ICM '05
Country/Territory	Taiwan
City	Taipei
Period	10/07/05 → 12/07/05

Keywords

Biochip
Centrifugal-force
Microfluidic

Access to Document

10.1109/ICMECH.2005.1529382

Cite this

Lee, M. Y., Wang, C. Y., Lin, H. C., Chiang, H. W., Su, L. S., & Chang, T. W. (2005). Development of fabrication and detection system for centrifugal force and thermal management biochip. In Proceedings of the 2005 IEEE International Conference on Mechatronics, ICM '05 (pp. 903-908). Article 1529382 (Proceedings of the 2005 IEEE International Conference on Mechatronics, ICM '05; Vol. 2005). https://doi.org/10.1109/ICMECH.2005.1529382

@inproceedings{66c84ba395cd4be6918de20bac41e9a9,

title = "Development of fabrication and detection system for centrifugal force and thermal management biochip",

abstract = "The development of Micro-Electro-Mechanical Systems (MEMS) advances the success of microfabricated devices, and microfabricated devices offer many specific platforms that can integrate a laboratory on a chip and manage micro biochemical reaction analysis. Nevertheless, most microfabricated devices, especially in biochip design, are depending on semi-conductor or LIGA process so that the configuration of devices is complex and money-consumed. Furthermore, miniaturization in nano-scale isn't always significant in bio-medical reactions. Thus, the aim of our research is to develop a fabrication and detection system of centrifugal-force and thermal management biochip, which will improve the complex pumps and valves designed by semi-conductor application in lab-on-a-chip, and it saves time and money in the comparison of traditional lab technology. Our system uses the software-SolidWorks and computer numerical control (CNC) machine to design microfluidic patterns, the heat pressure machine with feedback control of temperature sensor to design the hermetically sealed biochip, and the centrifugal machine with server frequency conversion motor to lead sample mobility by centrifugal force instead of pumps and valves. The hardware of this system includes three parts: centrifugal machine, heat pressure machine, and microfluidic fabrication; the application of the biochip is to detect clinical and medicine bio-reactions. Our {"}fabrication and detection system for centrifugal-force and thermal management biochip{"} developed in this study is a on-table facility and can use in several areas of medical and clinical examinations, it can also combine with polymerase chain reaction (PCR) by adding temperature controlling procedure in the future.",

keywords = "Biochip, Centrifugal-force, Microfluidic",

author = "Lee, {Ming Yih} and Wang, {Chen Ya} and Lin, {Hung Chia} and Chiang, {Hung Wei} and Su, {Liang Shiuan} and Chang, {Tsung Wei}",

year = "2005",

doi = "10.1109/ICMECH.2005.1529382",

language = "英语",

isbn = "0780389980",

series = "Proceedings of the 2005 IEEE International Conference on Mechatronics, ICM '05",

pages = "903--908",

booktitle = "Proceedings of the 2005 IEEE International Conference on Mechatronics, ICM '05",

note = "2005 IEEE International Conference on Mechatronics, ICM '05 ; Conference date: 10-07-2005 Through 12-07-2005",

}

Lee, MY, Wang, CY, Lin, HC, Chiang, HW, Su, LS & Chang, TW 2005, Development of fabrication and detection system for centrifugal force and thermal management biochip. in Proceedings of the 2005 IEEE International Conference on Mechatronics, ICM '05., 1529382, Proceedings of the 2005 IEEE International Conference on Mechatronics, ICM '05, vol. 2005, pp. 903-908, 2005 IEEE International Conference on Mechatronics, ICM '05, Taipei, Taiwan, 10/07/05. https://doi.org/10.1109/ICMECH.2005.1529382

Development of fabrication and detection system for centrifugal force and thermal management biochip. / Lee, Ming Yih; Wang, Chen Ya; Lin, Hung Chia et al.
Proceedings of the 2005 IEEE International Conference on Mechatronics, ICM '05. 2005. p. 903-908 1529382 (Proceedings of the 2005 IEEE International Conference on Mechatronics, ICM '05; Vol. 2005).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AU - Lee, Ming Yih

AU - Wang, Chen Ya

AU - Lin, Hung Chia

AU - Chiang, Hung Wei

AU - Su, Liang Shiuan

AU - Chang, Tsung Wei

PY - 2005

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N2 - The development of Micro-Electro-Mechanical Systems (MEMS) advances the success of microfabricated devices, and microfabricated devices offer many specific platforms that can integrate a laboratory on a chip and manage micro biochemical reaction analysis. Nevertheless, most microfabricated devices, especially in biochip design, are depending on semi-conductor or LIGA process so that the configuration of devices is complex and money-consumed. Furthermore, miniaturization in nano-scale isn't always significant in bio-medical reactions. Thus, the aim of our research is to develop a fabrication and detection system of centrifugal-force and thermal management biochip, which will improve the complex pumps and valves designed by semi-conductor application in lab-on-a-chip, and it saves time and money in the comparison of traditional lab technology. Our system uses the software-SolidWorks and computer numerical control (CNC) machine to design microfluidic patterns, the heat pressure machine with feedback control of temperature sensor to design the hermetically sealed biochip, and the centrifugal machine with server frequency conversion motor to lead sample mobility by centrifugal force instead of pumps and valves. The hardware of this system includes three parts: centrifugal machine, heat pressure machine, and microfluidic fabrication; the application of the biochip is to detect clinical and medicine bio-reactions. Our "fabrication and detection system for centrifugal-force and thermal management biochip" developed in this study is a on-table facility and can use in several areas of medical and clinical examinations, it can also combine with polymerase chain reaction (PCR) by adding temperature controlling procedure in the future.

AB - The development of Micro-Electro-Mechanical Systems (MEMS) advances the success of microfabricated devices, and microfabricated devices offer many specific platforms that can integrate a laboratory on a chip and manage micro biochemical reaction analysis. Nevertheless, most microfabricated devices, especially in biochip design, are depending on semi-conductor or LIGA process so that the configuration of devices is complex and money-consumed. Furthermore, miniaturization in nano-scale isn't always significant in bio-medical reactions. Thus, the aim of our research is to develop a fabrication and detection system of centrifugal-force and thermal management biochip, which will improve the complex pumps and valves designed by semi-conductor application in lab-on-a-chip, and it saves time and money in the comparison of traditional lab technology. Our system uses the software-SolidWorks and computer numerical control (CNC) machine to design microfluidic patterns, the heat pressure machine with feedback control of temperature sensor to design the hermetically sealed biochip, and the centrifugal machine with server frequency conversion motor to lead sample mobility by centrifugal force instead of pumps and valves. The hardware of this system includes three parts: centrifugal machine, heat pressure machine, and microfluidic fabrication; the application of the biochip is to detect clinical and medicine bio-reactions. Our "fabrication and detection system for centrifugal-force and thermal management biochip" developed in this study is a on-table facility and can use in several areas of medical and clinical examinations, it can also combine with polymerase chain reaction (PCR) by adding temperature controlling procedure in the future.

KW - Biochip

KW - Centrifugal-force

KW - Microfluidic

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Lee MY, Wang CY, Lin HC, Chiang HW, Su LS, Chang TW. Development of fabrication and detection system for centrifugal force and thermal management biochip. In Proceedings of the 2005 IEEE International Conference on Mechatronics, ICM '05. 2005. p. 903-908. 1529382. (Proceedings of the 2005 IEEE International Conference on Mechatronics, ICM '05). doi: 10.1109/ICMECH.2005.1529382

Development of fabrication and detection system for centrifugal force and thermal management biochip

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Publication series

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Keywords

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