Development of fabrication technique in nano-scale resveratrol by collagen

Juin Hong Cherng, Shu Jen Chang, Jue Zong Yeh, Yao Wen Hung, Hsin Chih Lai, Nien Hsien Liou, Chung Hsing Li, Chung Ang Tsao, Cheng Che Liu*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

1 Scopus citations


Resveratrol (3,5,4'-trihydroxy-trans-stilbene, RSV), is found in various plants, including grapes, berries and peanuts. It is also present in wines,especially red wines. RSV has potent antioxidant, anti-inflammatory, and chemo-protective properties used as a biologically active supplement in the prophylaxis of myocardial infarction, diabetes, and tumours. The aim of this study was using nanotechnology to develop and examine a nanoparticle RSV.The techniques described the particles of nano RSV as having a size of 150-200 nm. In the evidence, we successfully developed a novel method of nano-RSV manufacture and demonstrated that this method could circumvent the physicochemical drawbacks of raw RSV with respect to dissolution, such as the reduction of particle size and gradually release from collagen materials.The scanning electron microscopy (SEM) data have shown the RSV nanoparticles in the collagen material, and Fourier transform infrared spectroscopy (FTIR) detected the adsorbed RSV nanoparticles at 950-1000 nm. In theory, collagen has similar properties to an emulsion/solvent that cause nanoformation of RSV under homogeneity of stirring. To study the biocompatibility, we also employed an in vitro model to estimate the potentialof the collagen materials contained with RSV nanoparticles to observe the cell growth. This paper presents an anticipation of nanotechnology for the nanoparticle RSV production that may provide high efficacy pharmacology in future.

Original languageEnglish
Pages (from-to)984-995
Number of pages12
JournalInternational Journal of Nanotechnology
Issue number10-11
StatePublished - 2013


  • Biocompability
  • Collagen
  • Nanotechnology
  • RSV
  • Resveratrol
  • SEM
  • Scanning electron microscopy


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