Development of nanoparticles incorporated with quercetin and ACE2-membrane as a novel therapy for COVID-19

Jia You Fang, Kuo Yen Huang, Tong Hong Wang, Zih Chan Lin, Chin Chuan Chen, Sui Yuan Chang, En Li Chen, Tai Ling Chao, Shuenn Chen Yang, Pan Chyr Yang*, Chi Yuan Chen*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review


Introduction: Angiotensin-converting enzyme 2 (ACE2) and AXL tyrosine kinase receptor are known to be involved in the SARS-CoV-2 entry of the host cell. Therefore, targeting ACE2 and AXL should be an effective strategy to inhibit virus entry into cells. However, developing agents that can simultaneously target ACE2 and AXL remains a formidable task. The natural compound quercetin has been shown to inhibit AXL expression. Materials and methods: In this study, we employed PLGA nanoparticles to prepare nanoparticles encapsulated with quercetin, coated with ACE2-containing cell membranes, or encapsulated with quercetin and then coated with ACE-2-containing cell membranes. These nanoparticles were tested for their abilities to neutralize or inhibit viral infection. Results: Our data showed that nanoparticles encapsulated with quercetin and then coated with ACE2-containing cell membrane inhibited the expression of AXL without causing cytotoxic activity. Nanoparticles incorporated with both quercetin and ACE2-containing cell membrane were found to be able to neutralize pseudo virus infection and were more effective than free quercetin and nanoparticles encapsulated with quercetin at inhibition of pseudo virus and SARS-CoV-2 infection. Conclusions: We have shown that the biomimetic nanoparticles incorporated with both ACE-2 membrane and quercetin showed the most antiviral activity and may be further explored for clinical application.

Original languageEnglish
Article number169
Pages (from-to)169
JournalJournal of Nanobiotechnology
Issue number1
StatePublished - 12 04 2024
Externally publishedYes

Bibliographical note

© 2024. The Author(s).


  • ACE2
  • AXL
  • COVID-19
  • Nanoparticles
  • Quercetin
  • Angiotensin-Converting Enzyme 2
  • SARS-CoV-2
  • Humans
  • Quercetin/pharmacology


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