Development of optical fibre sensors for online pH monitoring in microbioreactors

Min Hsien Wu; Junbo Wang; Jr Lung Lin; Zhanfeng Cui; Zheng Cui

doi:10.1109/NEMS.2007.352140

Development of optical fibre sensors for online pH monitoring in microbioreactors

Min Hsien Wu
, Junbo Wang
, Jr Lung Lin
, Zhanfeng Cui^*
, Zheng Cui^*

^*Corresponding author for this work

CCLRC Rutherford Appleton Laboratory
CAS - Institute of Electronics
I-Shou University
University of Oxford

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Scopus citations

Abstract

The development of non-invasive optical fibre sensor array for on-line monitoring of pH in microbioreactors is described. The working principle is based on the optical absorption of phenol red contained in culture medium. Different from other devices of the similar working principle, the proposed device requires less liquid volume (less than 0.8 μl), is non-invasive, and particularly can be configured as an array. The computer simulation and experimental results revealed that the design of oval detection chamber can substabtially reduce the response time. Also, the system was proved to be able to detect pH change (pH 6.8-7.8) experienced in normal cell culture.

Original language	English
Title of host publication	Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007
Pages	805-808
Number of pages	4
DOIs	https://doi.org/10.1109/NEMS.2007.352140
State	Published - 2007
Externally published	Yes
Event	2007 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007 - Bangkok, Thailand Duration: 16 01 2007 → 19 01 2007

Publication series

Name	Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007

Conference

Conference	2007 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007
Country/Territory	Thailand
City	Bangkok
Period	16/01/07 → 19/01/07

Access to Document

10.1109/NEMS.2007.352140

Cite this

Wu, M. H., Wang, J., Lin, J. L., Cui, Z., & Cui, Z. (2007). Development of optical fibre sensors for online pH monitoring in microbioreactors. In Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007 (pp. 805-808). Article 4160443 (Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007). https://doi.org/10.1109/NEMS.2007.352140

Wu, Min Hsien ; Wang, Junbo ; Lin, Jr Lung et al. / Development of optical fibre sensors for online pH monitoring in microbioreactors. Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007. 2007. pp. 805-808 (Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007).

@inproceedings{0359671e8b6243c3bb8ac0b2223b9bd3,

title = "Development of optical fibre sensors for online pH monitoring in microbioreactors",

abstract = "The development of non-invasive optical fibre sensor array for on-line monitoring of pH in microbioreactors is described. The working principle is based on the optical absorption of phenol red contained in culture medium. Different from other devices of the similar working principle, the proposed device requires less liquid volume (less than 0.8 μl), is non-invasive, and particularly can be configured as an array. The computer simulation and experimental results revealed that the design of oval detection chamber can substabtially reduce the response time. Also, the system was proved to be able to detect pH change (pH 6.8-7.8) experienced in normal cell culture.",

author = "Wu, \{Min Hsien\} and Junbo Wang and Lin, \{Jr Lung\} and Zhanfeng Cui and Zheng Cui",

year = "2007",

doi = "10.1109/NEMS.2007.352140",

language = "英语",

isbn = "1424406102",

series = "Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007",

pages = "805--808",

booktitle = "Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007",

note = "2007 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007 ; Conference date: 16-01-2007 Through 19-01-2007",

}

Wu, MH, Wang, J, Lin, JL, Cui, Z & Cui, Z 2007, Development of optical fibre sensors for online pH monitoring in microbioreactors. in Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007., 4160443, Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007, pp. 805-808, 2007 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007, Bangkok, Thailand, 16/01/07. https://doi.org/10.1109/NEMS.2007.352140

Development of optical fibre sensors for online pH monitoring in microbioreactors. / Wu, Min Hsien; Wang, Junbo; Lin, Jr Lung et al.
Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007. 2007. p. 805-808 4160443 (Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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PY - 2007

Y1 - 2007

N2 - The development of non-invasive optical fibre sensor array for on-line monitoring of pH in microbioreactors is described. The working principle is based on the optical absorption of phenol red contained in culture medium. Different from other devices of the similar working principle, the proposed device requires less liquid volume (less than 0.8 μl), is non-invasive, and particularly can be configured as an array. The computer simulation and experimental results revealed that the design of oval detection chamber can substabtially reduce the response time. Also, the system was proved to be able to detect pH change (pH 6.8-7.8) experienced in normal cell culture.

AB - The development of non-invasive optical fibre sensor array for on-line monitoring of pH in microbioreactors is described. The working principle is based on the optical absorption of phenol red contained in culture medium. Different from other devices of the similar working principle, the proposed device requires less liquid volume (less than 0.8 μl), is non-invasive, and particularly can be configured as an array. The computer simulation and experimental results revealed that the design of oval detection chamber can substabtially reduce the response time. Also, the system was proved to be able to detect pH change (pH 6.8-7.8) experienced in normal cell culture.

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DO - 10.1109/NEMS.2007.352140

M3 - 会议稿件

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Wu MH, Wang J, Lin JL, Cui Z, Cui Z. Development of optical fibre sensors for online pH monitoring in microbioreactors. In Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007. 2007. p. 805-808. 4160443. (Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007). doi: 10.1109/NEMS.2007.352140

Development of optical fibre sensors for online pH monitoring in microbioreactors

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