Developmental programming of the metabolic syndrome: Can we reprogram with resveratrol?

You Lin Tain, Chien Ning Hsu*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

35 Scopus citations


Metabolic syndrome (MetS) is a mounting epidemic worldwide. MetS can start in early life, in a microenvironment that is now known as the developmental origins of health and disease (DOHaD). The concept of DOHaD also offers opportunities for reprogramming strategies that aim to reverse programming processes in early life. Resveratrol, a polyphenolic compound has a wide spectrum of beneficial effects on human health. In this review, we first summarize the epidemiological and experimental evidence supporting the developmental programming of MetS. This review also presents an overview of the evidence linking different molecular targets of resveratrol to developmental programming of MetS-related disorders. This will be followed by studies documenting resveratrol as a reprogramming agent to protect against MetS-related disorders. Further clinical studies are required in order to bridge the gap between animal models and clinical trials in order to establish the effective dose and therapeutic duration for resveratrol as a reprogramming therapy on MetS disorders from developmental origins.

Original languageEnglish
Article number2584
JournalInternational Journal of Molecular Sciences
Issue number9
StatePublished - 09 2018

Bibliographical note

Publisher Copyright:
© 2018 by the authors. Licensee MDPI, Basel, Switzerland.


  • Developmental origins of health and disease (DOHaD)
  • Hypertension
  • Metabolic syndrome
  • Nitric oxide
  • Nutrient-sensing signal
  • Obesity
  • Oxidative stress
  • Renin-angiotensin system
  • Resveratrol


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