Different clinical and laboratory manifestations between dengue haemorrhagic fever and dengue fever with bleeding tendency

Rong Fu Chen, Kuender D. Yang, Lin Wang, Jien Wei Liu, Chi Chin Chiu, Jiin Tsuey Cheng*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

67 Scopus citations

Abstract

The incidence of dengue fever (DF) is estimated to have increased 30-fold in the past 50 years. The incidence of dengue haemorrhagic fever (DHF), a life-threatening complication of DF, is also increasing. The need for better classification of the severity of dengue infections has been proposed in order to clarify different entities of dengue infections. We defined a class of patients with DF with bleeding tendency (DF w/B) to differentiate further the varying pathogenesis among DF, DF w/B and DHF. In a hospital-based study in Taiwan, we compared clinical features, biochemistry and immune mediators among patients with DHF, DF w/B and DF. Results showed that DF w/B patients, similar to DHF patients, had a higher rate of secondary dengue infection (P < 0.001) as well as higher IL-10 (P = 0.023) and lower IFNγ (P = 0.009) levels than DF patients. In contrast, DHF patients had significantly higher soluble vascular cell adhesion molecule 1 levels than DF w/B patients (P = 0.038) and DF patients (P < 0.001). This study provides new insight into the different immune mechanisms of DF, DF w/B and DHF. DF involves a Th1 reaction and DF w/B involves an altered Th2 reaction, whereas DHF involves an altered Th2 reaction and augmented vascular insult.

Original languageEnglish
Pages (from-to)1106-1113
Number of pages8
JournalTransactions of the Royal Society of Tropical Medicine and Hygiene
Volume101
Issue number11
DOIs
StatePublished - 11 2007

Keywords

  • Cytokines
  • Dengue haemorrhagic fever
  • Dengue virus
  • Haemorrhage
  • Taiwan
  • Vascular mediators

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