Abstract
The aim of this study was to compare the accuracy of 18-fluoro-2-deoxyglucose (FDG) positron emission tomography (PET) and thallium-201 (Tl-201) single photon emission computed tomography (SPECT) in differentiating recurrent/ residual nasopharyngeal carcinomas (NPC) from post-radiotherapy (RT) changes in patients with indeterminate computed tomography (CT) findings. Twenty NPC patients with indeterminate CT findings were included at least 4 months after RT. CT, FDG-PET, Tl-201 SPECT and biopsy were performed within 1 week. The final diagnoses were based on biopsy findings and clinical follow-up for at least 6 months. For differentiating recurrent/residual NPC from post-RT changes in patients with indeterminate CT findings the sensitivity, specificity and accuracy of FDG-PET were 100.0%, 92. 3% and 96.0% respectively. The sensitivity, specificity and accuracy of Tl-201 SPECT were 91.7%, 92.3% and 92.0% respectively. Based on this study's findings, we can conclude FDG-PET is more sensitive but equally specific as Tl-201 SPECT is differentiating recurrent/residual NPC from post-RT changes in patients with indeterminate CT findings.
| Original language | English |
|---|---|
| Pages (from-to) | 3513-3516 |
| Number of pages | 4 |
| Journal | Anticancer Research |
| Volume | 23 |
| Issue number | 4 |
| State | Published - 07 2003 |
| Externally published | Yes |
Keywords
- 18-fluoro-2-deoxyglucose
- Computed tomography
- Nasopharyngeal carcinomas
- Positron emission tomography
- Single photon emission computed tomography
- Thallium-201
