Diffusion-Weighted Magnetic Resonance Imaging in Liver Graft Rejection

C. C. Lin, H. Y. Ou, Y. H. Chuang, H. J. Chiang, C. C. Yu, M. Lazo, L. L.C. Tsang, T. L. Huang, C. C. Lin, C. L. Chen, Y. F. Cheng*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

4 Scopus citations


Objective: The purpose of this study is to evaluate the use of diffusion-weighted magnetic resonance imaging (DWMRI) in the assessment of graft rejection after liver transplantation (LT). Methods: From June 2017 to January 2018, 32 patients were included in the study with a mean age of 52.3 years. All patients underwent LT. The DWMRI was performed using the apparent diffusion coefficient map and measuring the different b-values (b-400, b-600, b-800, and b-1000). These measurements were compared with the histopathology results. Statistical analysis included t test, analysis of variance, and area under the curve for receiver operating characteristic (ROC). Results: There were 17 patients without rejection and 15 patients with liver graft rejection diagnosed by histopathology. The mean (SD) results between the nonrejection and rejection groups were as follows: b-400 = 1.568 (0.265) vs 1.519 (0.119) (P =.089), b-600 = 1.380 (0.181) vs 1.284 (0.106) (P =.039), b-800 = 1.262 (0.170) vs 1.170 (0.086) (P =.035), b-1000 = 1.109 (0.129) vs 1.098 (0.078) (P =.095); B-values × 10−3 mm2/s. Only b-600 (P =.04) and b-800 (P =.04) values have significant differences between the 2 groups. B-600 showed 90.48% sensitivity and 83.33% specificity (ROC area under the curve = 0.784; P <.001), and b-800 showed 90.38% sensitivity and 83.03% specificity (ROC area under the curve = 0.816; P <.001). The values obtained with the apparent diffusion coefficient in b-800 were clearly differentiated between the mild, moderate, and severe degrees of rejection (P <.001). Conclusion: Measurement of b-600 and b-800 values using DWMRI may be used for the diagnosis of graft rejection after LT.

Original languageEnglish
Pages (from-to)2675-2678
Number of pages4
JournalTransplantation Proceedings
Issue number9
StatePublished - 11 2018
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2018 Elsevier Inc.


Dive into the research topics of 'Diffusion-Weighted Magnetic Resonance Imaging in Liver Graft Rejection'. Together they form a unique fingerprint.

Cite this