Direct regulation of HSP60 expression by c-MYC induces transformation

Ya Ping Tsai; Shu Chun Teng; Kou Juey Wu

doi:10.1016/j.febslet.2008.11.004

Direct regulation of HSP60 expression by c-MYC induces transformation

Ya Ping Tsai
, Shu Chun Teng
, Kou Juey Wu^*

^*Corresponding author for this work

National Yang Ming Chiao Tung University
National Taiwan University

Research output: Contribution to journal › Journal Article › peer-review

34 Scopus citations

Abstract

The c-MYC proto-oncogene encodes a ubiquitous transcription factor involved in cell proliferation and tumorigenesis. Heat shock protein 60 (HSP60) plays an essential role in assisting many newly synthesized proteins to reach their native forms. Increased HSP60 expression is observed in different types of human cancer. Here we show that c-MYC directly activates HSP60 transcription through an E-box (CACGTG) site located in the proximal promoter of the HSP60 gene. Overexpression of HSP60 induces transformation. Short-interference RNA (siRNA) mediated repression of HSP60 reduces transformation caused by c-MYC overexpression. These results indicate that c-MYC may promote transformation through the induction of HSP60 expression.

Original language	English
Pages (from-to)	4083-4088
Number of pages	6
Journal	FEBS Letters
Volume	582
Issue number	29
DOIs	https://doi.org/10.1016/j.febslet.2008.11.004
State	Published - 10 12 2008
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

HSP60
Transformation
c-MYC

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10.1016/j.febslet.2008.11.004

Cite this

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title = "Direct regulation of HSP60 expression by c-MYC induces transformation",

abstract = "The c-MYC proto-oncogene encodes a ubiquitous transcription factor involved in cell proliferation and tumorigenesis. Heat shock protein 60 (HSP60) plays an essential role in assisting many newly synthesized proteins to reach their native forms. Increased HSP60 expression is observed in different types of human cancer. Here we show that c-MYC directly activates HSP60 transcription through an E-box (CACGTG) site located in the proximal promoter of the HSP60 gene. Overexpression of HSP60 induces transformation. Short-interference RNA (siRNA) mediated repression of HSP60 reduces transformation caused by c-MYC overexpression. These results indicate that c-MYC may promote transformation through the induction of HSP60 expression.",

keywords = "HSP60, Transformation, c-MYC",

author = "Tsai, \{Ya Ping\} and Teng, \{Shu Chun\} and Wu, \{Kou Juey\}",

year = "2008",

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language = "英语",

volume = "582",

pages = "4083--4088",

journal = "FEBS Letters",

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AU - Tsai, Ya Ping

AU - Teng, Shu Chun

AU - Wu, Kou Juey

PY - 2008/12/10

Y1 - 2008/12/10

N2 - The c-MYC proto-oncogene encodes a ubiquitous transcription factor involved in cell proliferation and tumorigenesis. Heat shock protein 60 (HSP60) plays an essential role in assisting many newly synthesized proteins to reach their native forms. Increased HSP60 expression is observed in different types of human cancer. Here we show that c-MYC directly activates HSP60 transcription through an E-box (CACGTG) site located in the proximal promoter of the HSP60 gene. Overexpression of HSP60 induces transformation. Short-interference RNA (siRNA) mediated repression of HSP60 reduces transformation caused by c-MYC overexpression. These results indicate that c-MYC may promote transformation through the induction of HSP60 expression.

AB - The c-MYC proto-oncogene encodes a ubiquitous transcription factor involved in cell proliferation and tumorigenesis. Heat shock protein 60 (HSP60) plays an essential role in assisting many newly synthesized proteins to reach their native forms. Increased HSP60 expression is observed in different types of human cancer. Here we show that c-MYC directly activates HSP60 transcription through an E-box (CACGTG) site located in the proximal promoter of the HSP60 gene. Overexpression of HSP60 induces transformation. Short-interference RNA (siRNA) mediated repression of HSP60 reduces transformation caused by c-MYC overexpression. These results indicate that c-MYC may promote transformation through the induction of HSP60 expression.

KW - HSP60

KW - Transformation

KW - c-MYC

UR - https://www.scopus.com/pages/publications/56949085161

U2 - 10.1016/j.febslet.2008.11.004

DO - 10.1016/j.febslet.2008.11.004

M3 - 文章

C2 - 19022255

AN - SCOPUS:56949085161

SN - 0014-5793

VL - 582

SP - 4083

EP - 4088

JO - FEBS Letters

JF - FEBS Letters

IS - 29

ER -

Direct regulation of HSP60 expression by c-MYC induces transformation

Abstract

UN SDGs

Keywords

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