Discontinuous or semi-discontinuous DNA replication in Escherichia coli?

Tzu Chien V. Wang*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

38 Scopus citations

Abstract

The postulate that a stalled/collapsed replication fork will be generated when the replication complex encounters a UV-induced lesion in the template for leading-strand DNA synthesis is based on the model of semi-discontinuous DNA replication. A review of existing data indicates that the semi-discontinuous DNA replication model is supported by data from in vitro studies, while the discontinuous DNA replication model is supported by in vivo studies in Escherichia coli Until the question of whether DNA replicates discontinuously in one or both strands is clearly resolved, any model building based on either one of the two DNA replication models should be treated with caution.

Original languageEnglish
Pages (from-to)633-636
Number of pages4
JournalBioEssays
Volume27
Issue number6
DOIs
StatePublished - 06 2005
Externally publishedYes

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