Discovery of new eunicellins from an Indonesian octocoral Cladiella sp.

Yung Husan Chen; Chia Ying Tai; Yin Di Su; Yu Chia Chang; Mei Chin Lu; Ching Feng Weng; Jui Hsin Su; Tsong Long Hwang; Yang Chang Wu; Ping Jyun Sung

doi:10.3390/md9060934

Discovery of new eunicellins from an Indonesian octocoral Cladiella sp.

Yung Husan Chen, Chia Ying Tai, Yin Di Su, Yu Chia Chang, Mei Chin Lu, Ching Feng Weng, Jui Hsin Su, Tsong Long Hwang, Yang Chang Wu^*, Ping Jyun Sung

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

26 Scopus citations

Abstract

Two new 11-hydroxyeunicellin diterpenoids, cladieunicellin F (1) and (-)-solenopodin C (2), were isolated from an Indonesian octocoral Cladiella sp. The structures of eunicellins 1 and 2 were established by spectroscopic methods, and eunicellin 2 was found to be an enantiomer of the known eunicellin solenopodin C (3). Eunicellin 2 displayed inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils. The previously reported structures of two eunicellin-based compounds, cladielloides A and B, are corrected in this study.

Original language	English
Pages (from-to)	934-943
Number of pages	10
Journal	Marine Drugs
Volume	9
Issue number	6
DOIs	https://doi.org/10.3390/md9060934
State	Published - 06 2011

Keywords

Cladiella
Cladieunicellin
Elastase
Eunicellin
Octocoral
Superoxide anion

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10.3390/md9060934

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@article{a2029eb5d67047608b8c951bdb69d258,

title = "Discovery of new eunicellins from an Indonesian octocoral Cladiella sp.",

abstract = "Two new 11-hydroxyeunicellin diterpenoids, cladieunicellin F (1) and (-)-solenopodin C (2), were isolated from an Indonesian octocoral Cladiella sp. The structures of eunicellins 1 and 2 were established by spectroscopic methods, and eunicellin 2 was found to be an enantiomer of the known eunicellin solenopodin C (3). Eunicellin 2 displayed inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils. The previously reported structures of two eunicellin-based compounds, cladielloides A and B, are corrected in this study.",

keywords = "Cladiella, Cladieunicellin, Elastase, Eunicellin, Octocoral, Superoxide anion",

author = "Chen, {Yung Husan} and Tai, {Chia Ying} and Su, {Yin Di} and Chang, {Yu Chia} and Lu, {Mei Chin} and Weng, {Ching Feng} and Su, {Jui Hsin} and Hwang, {Tsong Long} and Wu, {Yang Chang} and Sung, {Ping Jyun}",

year = "2011",

month = jun,

doi = "10.3390/md9060934",

language = "英语",

volume = "9",

pages = "934--943",

journal = "Marine Drugs",

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TY - JOUR

T1 - Discovery of new eunicellins from an Indonesian octocoral Cladiella sp.

AU - Chen, Yung Husan

AU - Tai, Chia Ying

AU - Su, Yin Di

AU - Chang, Yu Chia

AU - Lu, Mei Chin

AU - Weng, Ching Feng

AU - Su, Jui Hsin

AU - Hwang, Tsong Long

AU - Wu, Yang Chang

AU - Sung, Ping Jyun

PY - 2011/6

Y1 - 2011/6

N2 - Two new 11-hydroxyeunicellin diterpenoids, cladieunicellin F (1) and (-)-solenopodin C (2), were isolated from an Indonesian octocoral Cladiella sp. The structures of eunicellins 1 and 2 were established by spectroscopic methods, and eunicellin 2 was found to be an enantiomer of the known eunicellin solenopodin C (3). Eunicellin 2 displayed inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils. The previously reported structures of two eunicellin-based compounds, cladielloides A and B, are corrected in this study.

AB - Two new 11-hydroxyeunicellin diterpenoids, cladieunicellin F (1) and (-)-solenopodin C (2), were isolated from an Indonesian octocoral Cladiella sp. The structures of eunicellins 1 and 2 were established by spectroscopic methods, and eunicellin 2 was found to be an enantiomer of the known eunicellin solenopodin C (3). Eunicellin 2 displayed inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils. The previously reported structures of two eunicellin-based compounds, cladielloides A and B, are corrected in this study.

KW - Cladiella

KW - Cladieunicellin

KW - Elastase

KW - Eunicellin

KW - Octocoral

KW - Superoxide anion

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U2 - 10.3390/md9060934

DO - 10.3390/md9060934

M3 - 文章

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AN - SCOPUS:79959745541

SN - 1660-3397

VL - 9

SP - 934

EP - 943

JO - Marine Drugs

JF - Marine Drugs

IS - 6

ER -

Discovery of new eunicellins from an Indonesian octocoral Cladiella sp.

Abstract

Keywords

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