Discovery of new eunicellins from an Indonesian octocoral Cladiella sp.

Yung Husan Chen; Chia Ying Tai; Yin Di Su; Yu Chia Chang; Mei Chin Lu; Ching Feng Weng; Jui Hsin Su; Tsong Long Hwang; Yang Chang Wu; Ping Jyun Sung

doi:10.3390/md9060934

Discovery of new eunicellins from an Indonesian octocoral Cladiella sp.

Yung Husan Chen
, Chia Ying Tai
, Yin Di Su
, Yu Chia Chang
, Mei Chin Lu
, Ching Feng Weng
, Jui Hsin Su
, Tsong Long Hwang
, Yang Chang Wu^*
, Ping Jyun Sung

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

27 Scopus citations

Abstract

Two new 11-hydroxyeunicellin diterpenoids, cladieunicellin F (1) and (-)-solenopodin C (2), were isolated from an Indonesian octocoral Cladiella sp. The structures of eunicellins 1 and 2 were established by spectroscopic methods, and eunicellin 2 was found to be an enantiomer of the known eunicellin solenopodin C (3). Eunicellin 2 displayed inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils. The previously reported structures of two eunicellin-based compounds, cladielloides A and B, are corrected in this study.

Original language	English
Pages (from-to)	934-943
Number of pages	10
Journal	Marine Drugs
Volume	9
Issue number	6
DOIs	https://doi.org/10.3390/md9060934
State	Published - 06 2011

Keywords

Cladiella
Cladieunicellin
Elastase
Eunicellin
Octocoral
Superoxide anion

Access to Document

10.3390/md9060934

Cite this

@article{a2029eb5d67047608b8c951bdb69d258,

title = "Discovery of new eunicellins from an Indonesian octocoral Cladiella sp.",

abstract = "Two new 11-hydroxyeunicellin diterpenoids, cladieunicellin F (1) and (-)-solenopodin C (2), were isolated from an Indonesian octocoral Cladiella sp. The structures of eunicellins 1 and 2 were established by spectroscopic methods, and eunicellin 2 was found to be an enantiomer of the known eunicellin solenopodin C (3). Eunicellin 2 displayed inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils. The previously reported structures of two eunicellin-based compounds, cladielloides A and B, are corrected in this study.",

keywords = "Cladiella, Cladieunicellin, Elastase, Eunicellin, Octocoral, Superoxide anion",

author = "Chen, \{Yung Husan\} and Tai, \{Chia Ying\} and Su, \{Yin Di\} and Chang, \{Yu Chia\} and Lu, \{Mei Chin\} and Weng, \{Ching Feng\} and Su, \{Jui Hsin\} and Hwang, \{Tsong Long\} and Wu, \{Yang Chang\} and Sung, \{Ping Jyun\}",

year = "2011",

month = jun,

doi = "10.3390/md9060934",

language = "英语",

volume = "9",

pages = "934--943",

journal = "Marine Drugs",

issn = "1660-3397",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "6",

}

TY - JOUR

T1 - Discovery of new eunicellins from an Indonesian octocoral Cladiella sp.

AU - Chen, Yung Husan

AU - Tai, Chia Ying

AU - Su, Yin Di

AU - Chang, Yu Chia

AU - Lu, Mei Chin

AU - Weng, Ching Feng

AU - Su, Jui Hsin

AU - Hwang, Tsong Long

AU - Wu, Yang Chang

AU - Sung, Ping Jyun

PY - 2011/6

Y1 - 2011/6

N2 - Two new 11-hydroxyeunicellin diterpenoids, cladieunicellin F (1) and (-)-solenopodin C (2), were isolated from an Indonesian octocoral Cladiella sp. The structures of eunicellins 1 and 2 were established by spectroscopic methods, and eunicellin 2 was found to be an enantiomer of the known eunicellin solenopodin C (3). Eunicellin 2 displayed inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils. The previously reported structures of two eunicellin-based compounds, cladielloides A and B, are corrected in this study.

AB - Two new 11-hydroxyeunicellin diterpenoids, cladieunicellin F (1) and (-)-solenopodin C (2), were isolated from an Indonesian octocoral Cladiella sp. The structures of eunicellins 1 and 2 were established by spectroscopic methods, and eunicellin 2 was found to be an enantiomer of the known eunicellin solenopodin C (3). Eunicellin 2 displayed inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils. The previously reported structures of two eunicellin-based compounds, cladielloides A and B, are corrected in this study.

KW - Cladiella

KW - Cladieunicellin

KW - Elastase

KW - Eunicellin

KW - Octocoral

KW - Superoxide anion

UR - https://www.scopus.com/pages/publications/79959745541

U2 - 10.3390/md9060934

DO - 10.3390/md9060934

M3 - 文章

C2 - 21747739

AN - SCOPUS:79959745541

SN - 1660-3397

VL - 9

SP - 934

EP - 943

JO - Marine Drugs

JF - Marine Drugs

IS - 6

ER -

Discovery of new eunicellins from an Indonesian octocoral Cladiella sp.

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this