Discovery of novel sesquiterpenoids from a gorgonian Menella sp.

Shih Yao Kao; Jui Hsin Su; Tsong Long Hwang; Jyh Horng Sheu; Yin Di Su; Chan Shing Lin; Yu Chia Chang; Wei Hsien Wang; Lee Shing Fang; Ping Jyun Sung

doi:10.1016/j.tet.2011.07.043

Discovery of novel sesquiterpenoids from a gorgonian Menella sp.

Shih Yao Kao, Jui Hsin Su, Tsong Long Hwang, Jyh Horng Sheu, Yin Di Su, Chan Shing Lin, Yu Chia Chang, Wei Hsien Wang, Lee Shing Fang, Ping Jyun Sung^*

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

24 Scopus citations

Abstract

A novel sesquiterpenoid, menelloide A (1), which was found to possess a new carbon skeleton, and a new guaiane-type sesquiterpenoid, menelloide B (2), along with (+)-chloranthalactone B (3), an enantiomer of the known sesquiterpenoid, chloranthalactone B (4), were isolated from a gorgonian coral identified as Menella sp. The structures of sesquiterpenoids 1-3 were established by spectroscopic methods and by comparison of the data with those of related metabolites. Sesquiterpenoids 1 and 3 displayed inhibitory effects on the generation of superoxide anion by human neutrophils.

Original language	English
Pages (from-to)	7311-7315
Number of pages	5
Journal	Tetrahedron
Volume	67
Issue number	38
DOIs	https://doi.org/10.1016/j.tet.2011.07.043
State	Published - 23 09 2011

Keywords

Guaiane
Menella
Menelloide
Sesquiterpenoid
Superoxide anion

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title = "Discovery of novel sesquiterpenoids from a gorgonian Menella sp.",

abstract = "A novel sesquiterpenoid, menelloide A (1), which was found to possess a new carbon skeleton, and a new guaiane-type sesquiterpenoid, menelloide B (2), along with (+)-chloranthalactone B (3), an enantiomer of the known sesquiterpenoid, chloranthalactone B (4), were isolated from a gorgonian coral identified as Menella sp. The structures of sesquiterpenoids 1-3 were established by spectroscopic methods and by comparison of the data with those of related metabolites. Sesquiterpenoids 1 and 3 displayed inhibitory effects on the generation of superoxide anion by human neutrophils.",

keywords = "Guaiane, Menella, Menelloide, Sesquiterpenoid, Superoxide anion",

author = "Kao, {Shih Yao} and Su, {Jui Hsin} and Hwang, {Tsong Long} and Sheu, {Jyh Horng} and Su, {Yin Di} and Lin, {Chan Shing} and Chang, {Yu Chia} and Wang, {Wei Hsien} and Fang, {Lee Shing} and Sung, {Ping Jyun}",

year = "2011",

month = sep,

day = "23",

doi = "10.1016/j.tet.2011.07.043",

language = "英语",

volume = "67",

pages = "7311--7315",

journal = "Tetrahedron",

issn = "0040-4020",

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TY - JOUR

T1 - Discovery of novel sesquiterpenoids from a gorgonian Menella sp.

AU - Kao, Shih Yao

AU - Su, Jui Hsin

AU - Hwang, Tsong Long

AU - Sheu, Jyh Horng

AU - Su, Yin Di

AU - Lin, Chan Shing

AU - Chang, Yu Chia

AU - Wang, Wei Hsien

AU - Fang, Lee Shing

AU - Sung, Ping Jyun

PY - 2011/9/23

Y1 - 2011/9/23

N2 - A novel sesquiterpenoid, menelloide A (1), which was found to possess a new carbon skeleton, and a new guaiane-type sesquiterpenoid, menelloide B (2), along with (+)-chloranthalactone B (3), an enantiomer of the known sesquiterpenoid, chloranthalactone B (4), were isolated from a gorgonian coral identified as Menella sp. The structures of sesquiterpenoids 1-3 were established by spectroscopic methods and by comparison of the data with those of related metabolites. Sesquiterpenoids 1 and 3 displayed inhibitory effects on the generation of superoxide anion by human neutrophils.

AB - A novel sesquiterpenoid, menelloide A (1), which was found to possess a new carbon skeleton, and a new guaiane-type sesquiterpenoid, menelloide B (2), along with (+)-chloranthalactone B (3), an enantiomer of the known sesquiterpenoid, chloranthalactone B (4), were isolated from a gorgonian coral identified as Menella sp. The structures of sesquiterpenoids 1-3 were established by spectroscopic methods and by comparison of the data with those of related metabolites. Sesquiterpenoids 1 and 3 displayed inhibitory effects on the generation of superoxide anion by human neutrophils.

KW - Guaiane

KW - Menella

KW - Menelloide

KW - Sesquiterpenoid

KW - Superoxide anion

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U2 - 10.1016/j.tet.2011.07.043

DO - 10.1016/j.tet.2011.07.043

M3 - 文章

AN - SCOPUS:80051799213

SN - 0040-4020

VL - 67

SP - 7311

EP - 7315

JO - Tetrahedron

JF - Tetrahedron

IS - 38

ER -

Discovery of novel sesquiterpenoids from a gorgonian Menella sp.

Abstract

Keywords

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