Discrepant clinical responses and blood chemokine profiles between two non-steroidal anti-inflammatory medications for children with mild persistent asthma

Chih Hsing Hung; Chi Yuan Li; Yuan Sheng Lai; Ping Ching Hsu; Yi Ming Hua; Kuender D. Yang

doi:10.1111/j.1399-3038.2005.00273.x

Discrepant clinical responses and blood chemokine profiles between two non-steroidal anti-inflammatory medications for children with mild persistent asthma

Chih Hsing Hung^*
, Chi Yuan Li
, Yuan Sheng Lai
, Ping Ching Hsu
, Yi Ming Hua
, Kuender D. Yang

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

19 Scopus citations

Abstract

In a randomized study, two oral medications, ketotifen and montelukast, were compared for children with mild persistent asthma. Montelukast revealed faster clinical responses than ketotifen, showing improved exhaled nitric oxide, peak expiratory flow, and asthma scores in 1 wk. After 8-wk of medication, both ketotifen and montelukast revealed improved clinical responses. However, 8 wk of ketotifen, but not montelukast, decreased plasma serum thymus and activation-regulated chemokine (317.854 ± 207.906 vs. 181.348 ± 167.109, p < 0.05), macrophage-derived chemokine (355.11 ± 174.30 vs. 169.19 ± 62.42, p < 0.05) levels. In conclusion, different oral non-steroidal anti-inflammatory drugs revealed faster or slower treatment responses due to different mechanisms.

Original language	English
Pages (from-to)	306-309
Number of pages	4
Journal	Pediatric Allergy and Immunology
Volume	16
Issue number	4
DOIs	https://doi.org/10.1111/j.1399-3038.2005.00273.x
State	Published - 06 2005
Externally published	Yes

Keywords

Ketotifen
Macrophage-derived chemokine
Montelukast
Peak expiratory flow
Thymus and activation-regulated chemokine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1399-3038.2005.00273.x

Cite this

@article{c9486d2ba1cb4a7f93a1e96936f24324,

title = "Discrepant clinical responses and blood chemokine profiles between two non-steroidal anti-inflammatory medications for children with mild persistent asthma",

abstract = "In a randomized study, two oral medications, ketotifen and montelukast, were compared for children with mild persistent asthma. Montelukast revealed faster clinical responses than ketotifen, showing improved exhaled nitric oxide, peak expiratory flow, and asthma scores in 1 wk. After 8-wk of medication, both ketotifen and montelukast revealed improved clinical responses. However, 8 wk of ketotifen, but not montelukast, decreased plasma serum thymus and activation-regulated chemokine (317.854 ± 207.906 vs. 181.348 ± 167.109, p < 0.05), macrophage-derived chemokine (355.11 ± 174.30 vs. 169.19 ± 62.42, p < 0.05) levels. In conclusion, different oral non-steroidal anti-inflammatory drugs revealed faster or slower treatment responses due to different mechanisms.",

keywords = "Ketotifen, Macrophage-derived chemokine, Montelukast, Peak expiratory flow, Thymus and activation-regulated chemokine",

author = "Hung, \{Chih Hsing\} and Li, \{Chi Yuan\} and Lai, \{Yuan Sheng\} and Hsu, \{Ping Ching\} and Hua, \{Yi Ming\} and Yang, \{Kuender D.\}",

year = "2005",

month = jun,

doi = "10.1111/j.1399-3038.2005.00273.x",

language = "英语",

volume = "16",

pages = "306--309",

journal = "Pediatric Allergy and Immunology",

issn = "0905-6157",

publisher = "Blackwell Munksgaard",

number = "4",

}

TY - JOUR

T1 - Discrepant clinical responses and blood chemokine profiles between two non-steroidal anti-inflammatory medications for children with mild persistent asthma

AU - Hung, Chih Hsing

AU - Li, Chi Yuan

AU - Lai, Yuan Sheng

AU - Hsu, Ping Ching

AU - Hua, Yi Ming

AU - Yang, Kuender D.

PY - 2005/6

Y1 - 2005/6

N2 - In a randomized study, two oral medications, ketotifen and montelukast, were compared for children with mild persistent asthma. Montelukast revealed faster clinical responses than ketotifen, showing improved exhaled nitric oxide, peak expiratory flow, and asthma scores in 1 wk. After 8-wk of medication, both ketotifen and montelukast revealed improved clinical responses. However, 8 wk of ketotifen, but not montelukast, decreased plasma serum thymus and activation-regulated chemokine (317.854 ± 207.906 vs. 181.348 ± 167.109, p < 0.05), macrophage-derived chemokine (355.11 ± 174.30 vs. 169.19 ± 62.42, p < 0.05) levels. In conclusion, different oral non-steroidal anti-inflammatory drugs revealed faster or slower treatment responses due to different mechanisms.

AB - In a randomized study, two oral medications, ketotifen and montelukast, were compared for children with mild persistent asthma. Montelukast revealed faster clinical responses than ketotifen, showing improved exhaled nitric oxide, peak expiratory flow, and asthma scores in 1 wk. After 8-wk of medication, both ketotifen and montelukast revealed improved clinical responses. However, 8 wk of ketotifen, but not montelukast, decreased plasma serum thymus and activation-regulated chemokine (317.854 ± 207.906 vs. 181.348 ± 167.109, p < 0.05), macrophage-derived chemokine (355.11 ± 174.30 vs. 169.19 ± 62.42, p < 0.05) levels. In conclusion, different oral non-steroidal anti-inflammatory drugs revealed faster or slower treatment responses due to different mechanisms.

KW - Ketotifen

KW - Macrophage-derived chemokine

KW - Montelukast

KW - Peak expiratory flow

KW - Thymus and activation-regulated chemokine

UR - https://www.scopus.com/pages/publications/20944431982

U2 - 10.1111/j.1399-3038.2005.00273.x

DO - 10.1111/j.1399-3038.2005.00273.x

M3 - 文章

C2 - 15943593

AN - SCOPUS:20944431982

SN - 0905-6157

VL - 16

SP - 306

EP - 309

JO - Pediatric Allergy and Immunology

JF - Pediatric Allergy and Immunology

IS - 4

ER -

Discrepant clinical responses and blood chemokine profiles between two non-steroidal anti-inflammatory medications for children with mild persistent asthma

Abstract

Keywords

UN SDGs

Access to Document

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