Disseminated xanthogranulomas associated with adult T-cell leukaemia/lymphoma: A case report and review the association of haematologic malignancies

C. C. Chiou, P. N. Wang, L. C. Yang*, T. T. Kuo, H. S. Hong

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

24 Scopus citations

Abstract

Xanthogranuloma (XG) is rarely observed in adults and has been reported to be associated with chronic myelogenous leukaemia (CML) and/or neurofibromatosis type 1 (NF1). A 68-year-old woman with adult T-cell leukaemia/lymphoma (ATLL) gradually developed disseminated XGs over the 3 years since disease onset. Histopathological examination of a skin biopsy revealed the presence of histiocytes in the dermis with a few Touton giant cells admixed with lymphoid cells. The lesions of XGs persisted despite chemotherapy with prednisolone and chlorambucil for her ATLL. This is the first report of disseminated XGs associated with ATLL. The association of disseminated XGs with haematologic malignancies was reviewed and the possible pathogenesis of this association will be discussed.

Original languageEnglish
Pages (from-to)532-535
Number of pages4
JournalJournal of the European Academy of Dermatology and Venereology
Volume21
Issue number4
DOIs
StatePublished - 04 2007
Externally publishedYes

Keywords

  • Adult T-cell leukaemia/lymphoma
  • Haematologic malignancy
  • Xanthogranuloma

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