Disseminated xanthogranulomas associated with adult T-cell leukaemia/lymphoma: A case report and review the association of haematologic malignancies

C. C. Chiou; P. N. Wang; L. C. Yang; T. T. Kuo; H. S. Hong

doi:10.1111/j.1468-3083.2006.02013.x

Disseminated xanthogranulomas associated with adult T-cell leukaemia/lymphoma: A case report and review the association of haematologic malignancies

C. C. Chiou, P. N. Wang, L. C. Yang^*, T. T. Kuo, H. S. Hong

^*Corresponding author for this work

Chang Gung Memorial Hospital

Research output: Contribution to journal › Journal Article › peer-review

25 Scopus citations

Abstract

Xanthogranuloma (XG) is rarely observed in adults and has been reported to be associated with chronic myelogenous leukaemia (CML) and/or neurofibromatosis type 1 (NF1). A 68-year-old woman with adult T-cell leukaemia/lymphoma (ATLL) gradually developed disseminated XGs over the 3 years since disease onset. Histopathological examination of a skin biopsy revealed the presence of histiocytes in the dermis with a few Touton giant cells admixed with lymphoid cells. The lesions of XGs persisted despite chemotherapy with prednisolone and chlorambucil for her ATLL. This is the first report of disseminated XGs associated with ATLL. The association of disseminated XGs with haematologic malignancies was reviewed and the possible pathogenesis of this association will be discussed.

Original language	English
Pages (from-to)	532-535
Number of pages	4
Journal	Journal of the European Academy of Dermatology and Venereology
Volume	21
Issue number	4
DOIs	https://doi.org/10.1111/j.1468-3083.2006.02013.x
State	Published - 04 2007
Externally published	Yes

Keywords

Adult T-cell leukaemia/lymphoma
Haematologic malignancy
Xanthogranuloma

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10.1111/j.1468-3083.2006.02013.x

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title = "Disseminated xanthogranulomas associated with adult T-cell leukaemia/lymphoma: A case report and review the association of haematologic malignancies",

abstract = "Xanthogranuloma (XG) is rarely observed in adults and has been reported to be associated with chronic myelogenous leukaemia (CML) and/or neurofibromatosis type 1 (NF1). A 68-year-old woman with adult T-cell leukaemia/lymphoma (ATLL) gradually developed disseminated XGs over the 3 years since disease onset. Histopathological examination of a skin biopsy revealed the presence of histiocytes in the dermis with a few Touton giant cells admixed with lymphoid cells. The lesions of XGs persisted despite chemotherapy with prednisolone and chlorambucil for her ATLL. This is the first report of disseminated XGs associated with ATLL. The association of disseminated XGs with haematologic malignancies was reviewed and the possible pathogenesis of this association will be discussed.",

keywords = "Adult T-cell leukaemia/lymphoma, Haematologic malignancy, Xanthogranuloma",

author = "Chiou, {C. C.} and Wang, {P. N.} and Yang, {L. C.} and Kuo, {T. T.} and Hong, {H. S.}",

year = "2007",

month = apr,

doi = "10.1111/j.1468-3083.2006.02013.x",

language = "英语",

volume = "21",

pages = "532--535",

journal = "Journal of the European Academy of Dermatology and Venereology",

issn = "0926-9959",

publisher = "John Wiley and Sons Inc",

number = "4",

}

Disseminated xanthogranulomas associated with adult T-cell leukaemia/lymphoma: A case report and review the association of haematologic malignancies. / Chiou, C. C.; Wang, P. N.; Yang, L. C. et al.
In: Journal of the European Academy of Dermatology and Venereology, Vol. 21, No. 4, 04.2007, p. 532-535.

Research output: Contribution to journal › Journal Article › peer-review

TY - JOUR

T1 - Disseminated xanthogranulomas associated with adult T-cell leukaemia/lymphoma

T2 - A case report and review the association of haematologic malignancies

AU - Chiou, C. C.

AU - Wang, P. N.

AU - Yang, L. C.

AU - Kuo, T. T.

AU - Hong, H. S.

PY - 2007/4

Y1 - 2007/4

N2 - Xanthogranuloma (XG) is rarely observed in adults and has been reported to be associated with chronic myelogenous leukaemia (CML) and/or neurofibromatosis type 1 (NF1). A 68-year-old woman with adult T-cell leukaemia/lymphoma (ATLL) gradually developed disseminated XGs over the 3 years since disease onset. Histopathological examination of a skin biopsy revealed the presence of histiocytes in the dermis with a few Touton giant cells admixed with lymphoid cells. The lesions of XGs persisted despite chemotherapy with prednisolone and chlorambucil for her ATLL. This is the first report of disseminated XGs associated with ATLL. The association of disseminated XGs with haematologic malignancies was reviewed and the possible pathogenesis of this association will be discussed.

AB - Xanthogranuloma (XG) is rarely observed in adults and has been reported to be associated with chronic myelogenous leukaemia (CML) and/or neurofibromatosis type 1 (NF1). A 68-year-old woman with adult T-cell leukaemia/lymphoma (ATLL) gradually developed disseminated XGs over the 3 years since disease onset. Histopathological examination of a skin biopsy revealed the presence of histiocytes in the dermis with a few Touton giant cells admixed with lymphoid cells. The lesions of XGs persisted despite chemotherapy with prednisolone and chlorambucil for her ATLL. This is the first report of disseminated XGs associated with ATLL. The association of disseminated XGs with haematologic malignancies was reviewed and the possible pathogenesis of this association will be discussed.

KW - Adult T-cell leukaemia/lymphoma

KW - Haematologic malignancy

KW - Xanthogranuloma

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U2 - 10.1111/j.1468-3083.2006.02013.x

DO - 10.1111/j.1468-3083.2006.02013.x

M3 - 文章

C2 - 17373983

AN - SCOPUS:33947431939

SN - 0926-9959

VL - 21

SP - 532

EP - 535

JO - Journal of the European Academy of Dermatology and Venereology

JF - Journal of the European Academy of Dermatology and Venereology

IS - 4

ER -

Disseminated xanthogranulomas associated with adult T-cell leukaemia/lymphoma: A case report and review the association of haematologic malignancies

Abstract

Keywords

UN SDGs

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