Dissemination of extended-spectrum β-lactamase-producing enterobacteriaceae in intensive care units of a medical center in Taiwan

Tsu Lan Wu; Ju Hsin Chia; Lin Hui Su; Chishih Chu; An Jing Kuo; Cheng Hsun Chiu

doi:10.1089/mdr.2006.12.203

Dissemination of extended-spectrum β-lactamase-producing enterobacteriaceae in intensive care units of a medical center in Taiwan

Tsu Lan Wu, Ju Hsin Chia, Lin Hui Su, Chishih Chu, An Jing Kuo, Cheng Hsun Chiu^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

13 Scopus citations

Abstract

The prevalence of extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae in a tertiary hospital in Taiwan was assessed over a 16-month period. A total of 125 nonrepetitive ESBL-producing isolates of Enterobacter cloacae, Escherichia coli, and Klebsiella pneumoniae were available for investigation using molecular methods. Four predominant intensive care units (ICUs) were identified, and SHV-12 (59%), CTX-M-3 (36%), and CTX-M-14 (14%) were the three most frequent ESBLs. SHV-12 was predominant among E. cloacae in the burn unit and K. pneumoniae in the other three chest medicine-related ICUs. CTX-M-3 was predominant among E. coli and K. pneumoniae in three other ICUs. The dissemination of ESBL-producing Enterobacteriaceae in four ICUs of a medical center in Taiwan is a consequence of the clonal dissemination of a few epidemic strains along with the horizontal transmission of resistance genes-carrying plasmids among bacterial organisms.

Original language	English
Pages (from-to)	203-209
Number of pages	7
Journal	Microbial Drug Resistance
Volume	12
Issue number	3
DOIs	https://doi.org/10.1089/mdr.2006.12.203
State	Published - 09 2006

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title = "Dissemination of extended-spectrum β-lactamase-producing enterobacteriaceae in intensive care units of a medical center in Taiwan",

abstract = "The prevalence of extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae in a tertiary hospital in Taiwan was assessed over a 16-month period. A total of 125 nonrepetitive ESBL-producing isolates of Enterobacter cloacae, Escherichia coli, and Klebsiella pneumoniae were available for investigation using molecular methods. Four predominant intensive care units (ICUs) were identified, and SHV-12 (59%), CTX-M-3 (36%), and CTX-M-14 (14%) were the three most frequent ESBLs. SHV-12 was predominant among E. cloacae in the burn unit and K. pneumoniae in the other three chest medicine-related ICUs. CTX-M-3 was predominant among E. coli and K. pneumoniae in three other ICUs. The dissemination of ESBL-producing Enterobacteriaceae in four ICUs of a medical center in Taiwan is a consequence of the clonal dissemination of a few epidemic strains along with the horizontal transmission of resistance genes-carrying plasmids among bacterial organisms.",

author = "Wu, {Tsu Lan} and Chia, {Ju Hsin} and Su, {Lin Hui} and Chishih Chu and Kuo, {An Jing} and Chiu, {Cheng Hsun}",

year = "2006",

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T1 - Dissemination of extended-spectrum β-lactamase-producing enterobacteriaceae in intensive care units of a medical center in Taiwan

AU - Wu, Tsu Lan

AU - Chia, Ju Hsin

AU - Su, Lin Hui

AU - Chu, Chishih

AU - Kuo, An Jing

AU - Chiu, Cheng Hsun

PY - 2006/9

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N2 - The prevalence of extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae in a tertiary hospital in Taiwan was assessed over a 16-month period. A total of 125 nonrepetitive ESBL-producing isolates of Enterobacter cloacae, Escherichia coli, and Klebsiella pneumoniae were available for investigation using molecular methods. Four predominant intensive care units (ICUs) were identified, and SHV-12 (59%), CTX-M-3 (36%), and CTX-M-14 (14%) were the three most frequent ESBLs. SHV-12 was predominant among E. cloacae in the burn unit and K. pneumoniae in the other three chest medicine-related ICUs. CTX-M-3 was predominant among E. coli and K. pneumoniae in three other ICUs. The dissemination of ESBL-producing Enterobacteriaceae in four ICUs of a medical center in Taiwan is a consequence of the clonal dissemination of a few epidemic strains along with the horizontal transmission of resistance genes-carrying plasmids among bacterial organisms.

AB - The prevalence of extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae in a tertiary hospital in Taiwan was assessed over a 16-month period. A total of 125 nonrepetitive ESBL-producing isolates of Enterobacter cloacae, Escherichia coli, and Klebsiella pneumoniae were available for investigation using molecular methods. Four predominant intensive care units (ICUs) were identified, and SHV-12 (59%), CTX-M-3 (36%), and CTX-M-14 (14%) were the three most frequent ESBLs. SHV-12 was predominant among E. cloacae in the burn unit and K. pneumoniae in the other three chest medicine-related ICUs. CTX-M-3 was predominant among E. coli and K. pneumoniae in three other ICUs. The dissemination of ESBL-producing Enterobacteriaceae in four ICUs of a medical center in Taiwan is a consequence of the clonal dissemination of a few epidemic strains along with the horizontal transmission of resistance genes-carrying plasmids among bacterial organisms.

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SN - 1076-6294

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JO - Microbial Drug Resistance

JF - Microbial Drug Resistance

IS - 3

ER -

Dissemination of extended-spectrum β-lactamase-producing enterobacteriaceae in intensive care units of a medical center in Taiwan

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