Do initially non-dehydrated patients with acute ischemic stroke need fluid supplement?

Leng Chieh Lin, Yen Yun Tsai, Jen Tsung Yang, Yi Chuan Chen, Yi Fang Wu, Yen Chu Huang, Yuan Hsiung Tsai, Kuang Yu Hsiao, Chen June Seak*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

2 Scopus citations


Background: We previously found that dehydration is an independent predictor of early deterioration after acute ischemic stroke and rehydration helps to improve outcomes. There is limited evidence of how to treat patients who are initially non-dehydrated. In this study, we tested the hypothesis that rehydration therapy, based on the daily urine specific gravity, will improve the outcome of ischemic stroke patients who are initially non-dehydrated. Methods: We conducted a single-arm prospective study of patients with acute ischemic stroke with historical controls. For the first 5 days of study group, a daily urine specific gravity of > 1.020 g/ml was taken as indication for rehydration and patients were advised to drink water via oral or tubal feeding with a dose of 5 ml/kg body weight right away and after dinner. Control group patients were rehydrated without reference to urine specific gravity. An increase in National Institutes of Health Stroke Scale score of ≥ 4 within three days was defined as having stroke-in-evolution. Scores of ≤ 1 on the modified Rankin scale at 3 months were considered to indicate a favorable outcome. Results: A total of 125 patients were analyzed, 46 in the study group and 79 in the control group. The groups did not significantly differ in the stroke-in-evolution rate (4.3% vs. 8.2%, P = 0.474). The rate of favorable outcome at 3 months was significantly higher in the study group than in the control group (56.5% vs. 27.8%, P = 0.001). Conclusions: Urine specific gravity-based hydration might be a useful method to improve functional outcomes of patients with acute ischemic stroke who were non-dehydrated at admission.

Original languageEnglish
Pages (from-to)10-15
Number of pages6
JournalInternational Journal for Vitamin and Nutrition Research
Issue number1-2
StatePublished - 01 2021

Bibliographical note

Publisher Copyright:
© 2021 Hogrefe Verlag GmbH & Co. KG. All rights reserved.


  • Dehydration
  • Deterioration
  • Ischemic stroke
  • Modified Rankin scale
  • National institutes of health stroke scale
  • Outcome
  • Phase II clinical trial
  • Urine specific gravity


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