Doxycycline-embedded nanofibrous membranes help promote healing of tendon rupture

Chun Jui Weng, Demei Lee, Jui Ho, Shih Jung Liu*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

15 Scopus citations

Abstract

Background: Despite recent advancements in surgical techniques, the repair of tendon rupture remains a challenge for surgeons. The purpose of this study was to develop novel doxycycline-loaded biodegradable nanofibrous membranes and evaluate their efficacy for the repair of Achilles tendon rupture in a rat model. Materials and Methods: The drug-loaded nanofibers were prepared using the electrospin-ning process and drug release from the prepared membranes was investigated both in vitro and in vivo. Furthermore, the safety and efficacy of the drug-loaded nanofibrous membranes were evaluated in rats that underwent tendon surgeries. An animal behavior cage was employed to monitor the post-surgery activity of the animals. Results: The experimental results demonstrated that poly(D,L-lactide-co-glycolide) (PLGA) nanofibers released effective concentrations of doxycycline for more than 40 days post-surgery, and the systemic plasma drug concentration was low. Rats receiving implantation of doxycycline-loaded nanofibers also showed greater activities and stronger tendons post-operation. Conclusion: Nanofibers loaded with doxycycline may have great potential in the repair of Achilles tendon rupture.

Original languageEnglish
Pages (from-to)125-136
Number of pages12
JournalInternational Journal of Nanomedicine
Volume15
DOIs
StatePublished - 2020

Bibliographical note

Publisher Copyright:
© 2020 Weng et al.

Keywords

  • Doxycycline
  • Nanofibrous membrane
  • Tendon

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