DPP-4 enzyme deficiency protects kidney from acute ischemiareperfusion injury---role for remote intermittent bowel ischemia-reperfusion preconditioning

Yen Ta Chen; Christopher Glenn Wallace; Chih Chao Yang; Chih Hung Chen; Kuan Hung Chen; Pei Hsun Sung; Yung Lung Chen; Han Tan Chai; Sheng Ying Chung; Sarah Chua; Fan Yen Lee; Sheung Fat Ko; Mel S. Lee; Hon Kan Yip

doi:10.18632/oncotarget.18962

DPP-4 enzyme deficiency protects kidney from acute ischemiareperfusion injury---role for remote intermittent bowel ischemia-reperfusion preconditioning

Yen Ta Chen
, Christopher Glenn Wallace
, Chih Chao Yang
, Chih Hung Chen
, Kuan Hung Chen
, Pei Hsun Sung
, Yung Lung Chen
, Han Tan Chai
, Sheng Ying Chung
, Sarah Chua
, Fan Yen Lee
, Sheung Fat Ko
, Mel S. Lee
, Hon Kan Yip^*

^*Corresponding author for this work

Chang Gung University
Royal Devon & Exeter NHS Foundation Trust
Asia University Taiwan
China Medical University Taichung

Research output: Contribution to journal › Journal Article › peer-review

22 Scopus citations

Abstract

We analyzed the effects of acute ischemia-reperfusion (KIR) injury on the status of kidney function and architecture in dipeptidyl peptidase4-difficient (DPP4D) rats and the effect of remote small bowel ischemia-reperfusion (BIR) preconditioning. DPP4-deficient (DPP4D) and normal Fischer344 (F344) rats were divided into 6 groups: (1) sham-F344, (2) sham-DPP4D, (3) KIR-F344 (4) KIR-DPP4D, (5) DPP4D-KIRextendin- 9-39 and (6) BIR-KIR-F344. Blood creatinine and urea nitrogen levels and the urinary protein-to-creatinine ratio was higher in KIR-F344 rats than BIR-KIR-F344 or KIR-DPP4D rats 72 h after acute KIR. Conversely, the circulating glucagon-like peptide 1 (GLP-1) levels were higher in BIR-KIR-F344 and KIR-DPP4D than KIR-F344 rats after acute KIR. KIR-F344 rats showed greater inflammation, oxidative stress, apoptosis, DNA damage and kidney injury than other rat groups. Damage to the kidney architecture in KIR-F344 rats was greater than in BIR-KIR-F344 or KIR-DPP4D rats. Expression of antioxidant proteins and GLP-1 receptor was higher in kidneys from KIRDPP4D and BIR-KIR-F344 than KIR-F344 rats, which suggests better intrinsic responses. We therefore suggest that elevated circulating GLP-1 levels due to DPP4 deficiency and BIR preconditioning protect kidney function and architecture during acute IR injury.

Original language	English
Pages (from-to)	54821-54837
Number of pages	17
Journal	Oncotarget
Volume	8
Issue number	33
DOIs	https://doi.org/10.18632/oncotarget.18962
State	Published - 2017

Bibliographical note

Publisher Copyright:
© Chen et al.

Keywords

Acute kidney ischemia-reperfusion injury
Dipeptidyl peptidase 4 deficiency
Inflammation
Oxidative stress
Preconditioning

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10.18632/oncotarget.18962

Cite this

Chen, Y. T., Wallace, C. G., Yang, C. C., Chen, C. H., Chen, K. H., Sung, P. H., Chen, Y. L., Chai, H. T., Chung, S. Y., Chua, S., Lee, F. Y., Ko, S. F., Lee, M. S., & Yip, H. K. (2017). DPP-4 enzyme deficiency protects kidney from acute ischemiareperfusion injury---role for remote intermittent bowel ischemia-reperfusion preconditioning. Oncotarget, 8(33), 54821-54837. https://doi.org/10.18632/oncotarget.18962

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title = "DPP-4 enzyme deficiency protects kidney from acute ischemiareperfusion injury---role for remote intermittent bowel ischemia-reperfusion preconditioning",

abstract = "We analyzed the effects of acute ischemia-reperfusion (KIR) injury on the status of kidney function and architecture in dipeptidyl peptidase4-difficient (DPP4D) rats and the effect of remote small bowel ischemia-reperfusion (BIR) preconditioning. DPP4-deficient (DPP4D) and normal Fischer344 (F344) rats were divided into 6 groups: (1) sham-F344, (2) sham-DPP4D, (3) KIR-F344 (4) KIR-DPP4D, (5) DPP4D-KIRextendin- 9-39 and (6) BIR-KIR-F344. Blood creatinine and urea nitrogen levels and the urinary protein-to-creatinine ratio was higher in KIR-F344 rats than BIR-KIR-F344 or KIR-DPP4D rats 72 h after acute KIR. Conversely, the circulating glucagon-like peptide 1 (GLP-1) levels were higher in BIR-KIR-F344 and KIR-DPP4D than KIR-F344 rats after acute KIR. KIR-F344 rats showed greater inflammation, oxidative stress, apoptosis, DNA damage and kidney injury than other rat groups. Damage to the kidney architecture in KIR-F344 rats was greater than in BIR-KIR-F344 or KIR-DPP4D rats. Expression of antioxidant proteins and GLP-1 receptor was higher in kidneys from KIRDPP4D and BIR-KIR-F344 than KIR-F344 rats, which suggests better intrinsic responses. We therefore suggest that elevated circulating GLP-1 levels due to DPP4 deficiency and BIR preconditioning protect kidney function and architecture during acute IR injury.",

keywords = "Acute kidney ischemia-reperfusion injury, Dipeptidyl peptidase 4 deficiency, Inflammation, Oxidative stress, Preconditioning",

author = "Chen, \{Yen Ta\} and Wallace, \{Christopher Glenn\} and Yang, \{Chih Chao\} and Chen, \{Chih Hung\} and Chen, \{Kuan Hung\} and Sung, \{Pei Hsun\} and Chen, \{Yung Lung\} and Chai, \{Han Tan\} and Chung, \{Sheng Ying\} and Sarah Chua and Lee, \{Fan Yen\} and Ko, \{Sheung Fat\} and Lee, \{Mel S.\} and Yip, \{Hon Kan\}",

note = "Publisher Copyright: {\textcopyright} Chen et al.",

year = "2017",

doi = "10.18632/oncotarget.18962",

language = "英语",

volume = "8",

pages = "54821--54837",

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Chen, YT, Wallace, CG, Yang, CC, Chen, CH, Chen, KH, Sung, PH, Chen, YL, Chai, HT, Chung, SY, Chua, S, Lee, FY, Ko, SF, Lee, MS & Yip, HK 2017, 'DPP-4 enzyme deficiency protects kidney from acute ischemiareperfusion injury---role for remote intermittent bowel ischemia-reperfusion preconditioning', Oncotarget, vol. 8, no. 33, pp. 54821-54837. https://doi.org/10.18632/oncotarget.18962

TY - JOUR

T1 - DPP-4 enzyme deficiency protects kidney from acute ischemiareperfusion injury---role for remote intermittent bowel ischemia-reperfusion preconditioning

AU - Chen, Yen Ta

AU - Wallace, Christopher Glenn

AU - Yang, Chih Chao

AU - Chen, Chih Hung

AU - Chen, Kuan Hung

AU - Sung, Pei Hsun

AU - Chen, Yung Lung

AU - Chai, Han Tan

AU - Chung, Sheng Ying

AU - Chua, Sarah

AU - Lee, Fan Yen

AU - Ko, Sheung Fat

AU - Lee, Mel S.

AU - Yip, Hon Kan

PY - 2017

Y1 - 2017

N2 - We analyzed the effects of acute ischemia-reperfusion (KIR) injury on the status of kidney function and architecture in dipeptidyl peptidase4-difficient (DPP4D) rats and the effect of remote small bowel ischemia-reperfusion (BIR) preconditioning. DPP4-deficient (DPP4D) and normal Fischer344 (F344) rats were divided into 6 groups: (1) sham-F344, (2) sham-DPP4D, (3) KIR-F344 (4) KIR-DPP4D, (5) DPP4D-KIRextendin- 9-39 and (6) BIR-KIR-F344. Blood creatinine and urea nitrogen levels and the urinary protein-to-creatinine ratio was higher in KIR-F344 rats than BIR-KIR-F344 or KIR-DPP4D rats 72 h after acute KIR. Conversely, the circulating glucagon-like peptide 1 (GLP-1) levels were higher in BIR-KIR-F344 and KIR-DPP4D than KIR-F344 rats after acute KIR. KIR-F344 rats showed greater inflammation, oxidative stress, apoptosis, DNA damage and kidney injury than other rat groups. Damage to the kidney architecture in KIR-F344 rats was greater than in BIR-KIR-F344 or KIR-DPP4D rats. Expression of antioxidant proteins and GLP-1 receptor was higher in kidneys from KIRDPP4D and BIR-KIR-F344 than KIR-F344 rats, which suggests better intrinsic responses. We therefore suggest that elevated circulating GLP-1 levels due to DPP4 deficiency and BIR preconditioning protect kidney function and architecture during acute IR injury.

AB - We analyzed the effects of acute ischemia-reperfusion (KIR) injury on the status of kidney function and architecture in dipeptidyl peptidase4-difficient (DPP4D) rats and the effect of remote small bowel ischemia-reperfusion (BIR) preconditioning. DPP4-deficient (DPP4D) and normal Fischer344 (F344) rats were divided into 6 groups: (1) sham-F344, (2) sham-DPP4D, (3) KIR-F344 (4) KIR-DPP4D, (5) DPP4D-KIRextendin- 9-39 and (6) BIR-KIR-F344. Blood creatinine and urea nitrogen levels and the urinary protein-to-creatinine ratio was higher in KIR-F344 rats than BIR-KIR-F344 or KIR-DPP4D rats 72 h after acute KIR. Conversely, the circulating glucagon-like peptide 1 (GLP-1) levels were higher in BIR-KIR-F344 and KIR-DPP4D than KIR-F344 rats after acute KIR. KIR-F344 rats showed greater inflammation, oxidative stress, apoptosis, DNA damage and kidney injury than other rat groups. Damage to the kidney architecture in KIR-F344 rats was greater than in BIR-KIR-F344 or KIR-DPP4D rats. Expression of antioxidant proteins and GLP-1 receptor was higher in kidneys from KIRDPP4D and BIR-KIR-F344 than KIR-F344 rats, which suggests better intrinsic responses. We therefore suggest that elevated circulating GLP-1 levels due to DPP4 deficiency and BIR preconditioning protect kidney function and architecture during acute IR injury.

KW - Acute kidney ischemia-reperfusion injury

KW - Dipeptidyl peptidase 4 deficiency

KW - Inflammation

KW - Oxidative stress

KW - Preconditioning

UR - https://www.scopus.com/pages/publications/85029088749

U2 - 10.18632/oncotarget.18962

DO - 10.18632/oncotarget.18962

M3 - 文章

C2 - 28903385

AN - SCOPUS:85029088749

SN - 1949-2553

VL - 8

SP - 54821

EP - 54837

JO - Oncotarget

JF - Oncotarget

IS - 33

ER -

DPP-4 enzyme deficiency protects kidney from acute ischemiareperfusion injury---role for remote intermittent bowel ischemia-reperfusion preconditioning

Abstract

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Keywords

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