TY - JOUR
T1 - Dynamic Prevalence of and Factors Associated with Fatigue Following Traumatic Brain Injury
T2 - A Systematic Review and Meta-Analysis of Observational Studies
AU - Liu, I. Hsing
AU - Lin, Chia Jou
AU - Romadlon, Debby Syahru
AU - Lee, Shu Chun
AU - Huang, Hui Chung
AU - Chen, Pin Yuan
AU - Chiu, Hsiao Yean
N1 - Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2023/10/20
Y1 - 2023/10/20
N2 - Objective: To implement a systematic review and meta-Analysis to comprehensively synthesize the prevalence of and factors associated with fatigue following traumatic brain injury (TBI). Methods: We systematically searched the PubMed, EMBASE, Cochrane Library, Cumulated Index to Nursing and Allied Health Literature, PsycINFO, and ProQuest Dissertations and Theses A&I databases in all fields from their inception to March 31, 2021. We included observational studies investigating fatigue at specific time points following TBI or factors associated with post-TBI fatigue. All data were analyzed using a random-effects model. Results: This meta-Analysis included 29 studies that involved 12 662 patients with TBI and estimated the prevalence of post-TBI fatigue (mean age = 41.09 years); the meta-Analysis also included 23 studies that involved 6681 patients (mean age = 39.95 years) and investigated factors associated with post-TBI fatigue. In patients with mild-To-severe TBI, the fatigue prevalence rates at 2 weeks or less, 1 to 3 months, 6 months, 1 year, and 2 years or more after TBI were 52.2%, 34.6%, 36.0%, 36.1%, and 48.8%, respectively. Depression (r = 0.48), anxiety (r = 0.49), sleep disturbance (r = 0.57), and pain (r = 0.46) were significantly associated with post-TBI fatigue. No publication bias was identified among the studies, except for those assessing fatigue prevalence at 6 months after TBI. Conclusion: The pooled prevalence rates of post-TBI fatigue exhibited a U-shaped pattern, with the lowest prevalence rates occurring at 1 to 3 months after TBI. Depression, anxiety, sleep disturbance, and pain were associated with post-TBI fatigue. Younger patients and male patients were more likely to experience post-TBI fatigue. Our findings can assist healthcare providers with identifying appropriate and effective interventions targeting post-TBI fatigue at specific periods.
AB - Objective: To implement a systematic review and meta-Analysis to comprehensively synthesize the prevalence of and factors associated with fatigue following traumatic brain injury (TBI). Methods: We systematically searched the PubMed, EMBASE, Cochrane Library, Cumulated Index to Nursing and Allied Health Literature, PsycINFO, and ProQuest Dissertations and Theses A&I databases in all fields from their inception to March 31, 2021. We included observational studies investigating fatigue at specific time points following TBI or factors associated with post-TBI fatigue. All data were analyzed using a random-effects model. Results: This meta-Analysis included 29 studies that involved 12 662 patients with TBI and estimated the prevalence of post-TBI fatigue (mean age = 41.09 years); the meta-Analysis also included 23 studies that involved 6681 patients (mean age = 39.95 years) and investigated factors associated with post-TBI fatigue. In patients with mild-To-severe TBI, the fatigue prevalence rates at 2 weeks or less, 1 to 3 months, 6 months, 1 year, and 2 years or more after TBI were 52.2%, 34.6%, 36.0%, 36.1%, and 48.8%, respectively. Depression (r = 0.48), anxiety (r = 0.49), sleep disturbance (r = 0.57), and pain (r = 0.46) were significantly associated with post-TBI fatigue. No publication bias was identified among the studies, except for those assessing fatigue prevalence at 6 months after TBI. Conclusion: The pooled prevalence rates of post-TBI fatigue exhibited a U-shaped pattern, with the lowest prevalence rates occurring at 1 to 3 months after TBI. Depression, anxiety, sleep disturbance, and pain were associated with post-TBI fatigue. Younger patients and male patients were more likely to experience post-TBI fatigue. Our findings can assist healthcare providers with identifying appropriate and effective interventions targeting post-TBI fatigue at specific periods.
KW - associated factors
KW - fatigue
KW - meta-Analysis
KW - prevalence
KW - traumatic brain injury
KW - Prevalence
KW - Fatigue/epidemiology
KW - Humans
KW - Risk Factors
KW - Brain Injuries, Traumatic/complications
KW - Observational Studies as Topic
UR - http://www.scopus.com/inward/record.url?scp=85197991347&partnerID=8YFLogxK
U2 - 10.1097/HTR.0000000000000904
DO - 10.1097/HTR.0000000000000904
M3 - 文章
C2 - 37862135
AN - SCOPUS:85197991347
SN - 0885-9701
VL - 39
SP - E172-E181
JO - Journal of Head Trauma Rehabilitation
JF - Journal of Head Trauma Rehabilitation
IS - 4
ER -