Early-onset eczema is associated with increased milk sensitization and risk of rhinitis and asthma in early childhood

Chih Yung Chiu, Chia Hsuan Yang, Kuan Wen Su, Ming Han Tsai, Man Chin Hua, Sui Ling Liao, Shen Hao Lai, Li Chen Chen, Kuo Wei Yeh*, Jing Long Huang*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

11 Scopus citations

Abstract

Background: Atopic eczema and food allergy most commonly occur in the early childhood. However, the relationships between eczema onset and their relevance to the occurrence of atopic diseases relating to allergen sensitization remain unclear. Methods: We investigated 186 children who were followed up regularly at the clinic for 4 years in a birth cohort study. The children were classified into three groups: early-onset eczema (<2 years old, n = 55), late-onset eczema (≥2 years old, n = 40), and never eczema groups (n = 91). The associations between the different onsets of eczema and total immunoglobulin E levels, absolute eosinophil count, sensitization to food and inhalant allergens, and allergic outcomes were assessed. Results: A significantly higher prevalence of sensitization to food, especially milk was observed in children with early-onset eczema compared with those without eczema at age 1, 1.5, 2, 3, and 4 years. Furthermore, a significantly higher number of eosinophils was detected in children with early or late-onset eczema at the age of 1.5 years. Both the early- and late-onset eczema were significantly associated with a higher prevalence of allergic rhinitis at age 2, 3, and 4 years, and asthma at age 2. Moreover, the early-onset eczema group showed a significantly increased risk of allergic rhinitis (P = 0.010) and asthma (P = 0.032) at age 4. Conclusion: The children with early-onset eczema (<2 years old) appear to be associated with an increased prevalence of milk sensitization and risk of rhinitis and asthma in early childhood.

Original languageEnglish
Pages (from-to)1008-1013
Number of pages6
JournalJournal of Microbiology, Immunology and Infection
Volume53
Issue number6
DOIs
StatePublished - 12 2020

Bibliographical note

Publisher Copyright:
© 2019

Keywords

  • Absolute eosinophil count
  • Asthma
  • Early-onset eczema
  • Milk sensitization

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