Early transplantation of unrelated cord blood in a two-month-old infant with Wiskott-Aldrich syndrome

Tang Her Jaing*, Bih Yu Tsai, Shih Hsiang Chen, Wei I. Lee, Kuei Wen Chang, Shih Ming Chu

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

10 Scopus citations

Abstract

This report exemplified a success of unrelated CBT in a two-month-old boy with Wiskott-Aldrich Syndrome. Umbilical cord blood was chosen as the stem-cell source because of its immediate availability and reduced tendency to cause GVHD. The conditioning regimen was cyclophosphamide, busulfan, and antithymocyte globulin. GVHD prophylaxis consisted of cyclosporin and methylprednisolone. The patient received an HLA 1-locus-mismatched cord blood unit, and the total number of infused nucleated cells was 11.14 × 107/kg. Neutrophil engraftment was achieved on day +11, and a platelet count greater than 50 × 109/L was achieved on day +71. He is currently alive and doing well at nine months post-transplant and free of any bleeding episodes. This case suggests that unrelated donor CBT may be safe and technically feasible, even in early infancy, when an appropriately matched related or unrelated donor is unavailable.

Original languageEnglish
Pages (from-to)557-559
Number of pages3
JournalPediatric Transplantation
Volume11
Issue number5
DOIs
StatePublished - 08 2007

Keywords

  • Unrelated cord blood transplantation
  • Wiskott-Aldrich syndrome
  • Young infant

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